Bone disorders in experimentally induced liver disease in growing rats

Table 1 Serum parameters and body weight in UNT, DP-treated control and DPC-treated rats at wk 8 and 16 (mean±SD)

Parameter	UNT control	UNT control	DP control	DP control	DPC	DPC
	(wk 8)	(wk 16)	(wk 8)	(wk 16)	(wk 8)	(wk 16)
	n = 8	n = 6	n = 10	n = 10	n = 10	n = 11
Bilirubin (mmol/L)	1.8±1.2	2.1±1.3	1.85±0.9	0.88±0.3	48.14±66a	1.31±0.5
ALP (U/L)	735.7±89.3	619.5±96.3	493.9±52.3	402.8±80.2	1 354±1 108a	437.8±116.2
AST (U/L)	112.7±13.3	158.8±40.9	157.3±52.9	127.5±43.3	7 095±5 483a	115.8±15
ALT (U/L)	69.42±8.9	107.8±12.1	158.5±78.4	93.1±71.1	5 175±3 675a	81.54±17.9
Albumin (g/L)	32.85±0.4	34.66±1	33.6±2.2	37.4±1.2	27.8±3a	35.36±1.6
Body weight (g)	240.1±14.3	321.8±48.9	269.4±12.1	307.7±11.3	227.4±16.4	284.2±25.2

^aP<0.05 vs for comparison between DPC and both UNT and DP controls at wk 8.

Table 2 Femur length, cortical index, BMC, and ultimate bending load of femoral mid-diaphysis and corrected loading data for cortical index and BMC in UNT, DP-treated control and DPC-treated rats at wk 8 and 16 (mean±SD)

Parameter	UNT control	UNT control	DP control	DP control	DPC	DPC
	(wk 8)	(wk 16)	(wk 8)	(wk 16)	(wk 8)	(wk 16)
	n = 8	n = 6	n = 10	n = 10	n = 10	n = 11
Femur length(mm)	34.8±1.0	40.1±1.2	37.9±0.6	40.2±0.8	36.8±0.8	38.6±0.9
Cortical index (mm/mm)	0.277±0.026	0.325±0.029	0.287±0.015	0.33±0.018	0.285±0.021	0.286±0.036
BMC (mg/cm)	0.049±0.005	0.06±0.008	0.056±0.003	0.057±0.002	0.047±0.006	0.049±0.004
Femur Fmax (N)	88.3±14.3	123.2±13.0	111.8±7.9	118.5±6.02	93.8±5.41	96.5±12.6
Fmax/Cortical index (N/mm/mm)	328.7±53.4	382.6±62.5	390.4±32.4	359.8±24.25	331.1±35.4	339.9±46.5
Fmax/BMC (N/mg/cm)	1 796±239	2 049±95.2	2 000±124	2 075±114.6	2 019±195	1 961±115.9