Rapid Communication
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2005; 11(43): 6858-6862
Published online Nov 21, 2005. doi: 10.3748/wjg.v11.i43.6858
Table 1 Demographic and clinical characteristics (mean±SD, n)
HPS (n = 3)Non-HPS (n = 4)
Sex (M/F)2/14/–
Age (yr)50±2248±10
Smoking (n)14
Current-2
Past12
Etiology of chronic liver disease (n)
Hepatitis C11
Alcohol abuse13
Idiopathic portal hypertension1
Child–Pugh score A/B/C (n)1/2/–1/2/1
Presence of esophageal varices34
Gastrointestinal bleeding23
Ascites11
Hepatic encephalopathy
Cutaneous spider nevi33
Concomitant respiratory symptoms
Digital clubbing3
Dyspnea31
Cyanosis3
Indication of TIPS
Variceal bleeding3
Refractory ascites1
Hepatopulmonary syndrome3
Table 2 Pulmonary gas exchange before and after TIPS placement in patients without HPS (mean±SD)
Pre-TIPSPost-TIPS
PaO2 (mmHg)95±1695±27
PaCO2 (mmHg)29±631±7
AaPO2 (mmHg)18±1218±20
FEV1 (% pred)72±974±5
FVC (% pred)76±680±2
FEV1/FVC75±1076±8
DLCO (mL/(min×mmHg))22±420±5
DLCO (% pred)67±1363±9
Table 3 Pulmonary gas exchange and hemodynamics before and after TIPS placement in patients with HPS
Pre-TIPS
Post-TIPS <1 mo
Post-TIPS >4 mo
Patients# 1# 2# 3# 1# 2# 3# 1# 2# 3
FEV1 (% pred)6977100
FVC (% pred)6677113
FEV1/FVC778082
TLC (% pred)687083
DLCO (% pred)21.3248
PaO2 (mmHg)3259285861313334
PaCO2 (mmHg)2728353127382634
AaPO2 (mmHg)8854785369718773
PaO2 100% O2 breathing (mmHg)6460686
PAP (mmHg)14.5918822208
PVR (dyn.s/cm5)493111121823818
SVR (dyn.s/cm5)7734151 174400922549560
QT (L/min)9.010.46.4711.27.810.511.3
PP (mmHg)22161914112218.511
IVCP (mmHg)54372.51982.5
PPG (mmHg)17121678.5310.58.5