Clinical Research
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2005; 11(43): 6807-6814
Published online Nov 21, 2005. doi: 10.3748/wjg.v11.i43.6807
Table 1 Univariate analysis of potential risk factors for the development of esophageal adenocarcinoma in patients with columnar-lined esophagus
Non-malignantMalignantP
group (n = 553)group (n = 44)
Age
<60 (yr: n, %)189 (34.2)13 (29.5)0.532
>60 (yr: n, %)364 (65.8)31 (70.5)
Sex: male (%)299 (54.1)34 (77.3)0.003
Smoking+: n (%)161 (45.2)21 (51.2)0.466
Regular alcohol use±: n (%)52 (15.2)8 (20)0.43
NSAIDs: n (%)304 (55)25 (56.8)0.813
Specialized epithelium: n (%)467 (84.4)42 (95.5)0.047
Length of CLE Median (cm)560.001
Hiatul hernia: n (%)314 (56.8)22 (50)0.383
Esophagitis: n (%)330 (59.7)13 (29.5)<0.0001
Esophageal ulcer117 (21.2)11 (25)0.55
Esophageal stricture77 (13.9)16 (36.4)<0.0001
Hp in esophageal biopsy42 (7.6)2 (4.5)0.456
Table 2 Risk factors associated with the development of adenocarcinoma in patients with CLE; results of multivariable regression analysis
Risk factorsOdds ratio95%CI for Odds ratioP
Age ≥60 yr1.650.75–3.640.216
Male sex5.122.04–12.840.0005
Regular alcohol use1.150.46–2.900.76
NSAIDs1.410.68–2.930.352
Esophagitis0.280.13–0.570.0006
Esophageal stricture4.372.02–9.450.0002