Effect of IL-4 on altered expression of complement activation regulators in rat pancreatic cells during severe acute pancreatitis

Table 1 Serum amylase and lipase activities (u/L) and histological scores of pancreatic necrosis in the first series of experiment (mean±SE)

	Control group	Pancreatitis group
		3 h	6 h	12 h	24 h
Serum amylase	1360±259	4715±1 120b	7527±1 595b	13321±3 848b	13686±4 175b
Serum lipase	2.52±0.35	11.09±2.93b	31.17±5.66b	40.39±9.04b	38.06±9.67b
Scores of pancreatic necrosis	0.00±0.00	0.30±0.48b	1.40±0.70b	2.70±0.48b	2.80±0.79b

^bP<0.01 vs control. control.

Table 2 Correlation between expression of DAF, CD59, MCP, and pancreatic necrosis

		Histological scores of pancreatic necrosis
		0	1	2	3	4
MCP	–	1	5	6	12	2
	＋	8	3	3	0	0
	＋＋	6	2	0	0	0
	＋＋＋	2	0	0	0	0
DAF	–	0	6	7	12	2
	＋	6	4	2	0	0
	＋＋	10	0	0	0	0
	＋＋＋	1	0	0	0	0
CD59	–	2	6	6	12	2
	＋	5	3	3	0	0
	＋＋	7	1	0	0	0
	＋＋＋	3	0	0	0	0

Table 3 Serum amylase and lipase activities (u/L) and histological scores of pancreatic necrosis in the second series of experiment (mean±SE)

Group	n	Serum amylase	Serum lipase	Scores of pancreatic necrosis
A	21	7 393±1 433	32.15±5.42	1.52±0.75
B	20	4 482±1 224a	11.75±4.42a	0.45±0.69a
C	20	5 947±1 503a	22.28±7.10a	0.95±0.76a

^aP<0.05 vs group A.

Table 4 Effects of IL-4 on expression of MCP, DAF, and CD59 in pancreas during SAP

Group	n	Expression intensity of DAF			Expression intensity of CD59			Expression intensity of MCP
		–	+	++	–	+	++	–	+	++
A	21	12	7	2	12	6	3	11	6	4
B	20	2	7	11b	3	7	10a	5	8	7c
C	20	4	8	8a	9	6	5c	7	7	6c

^aP<0.05,

^bP<0.01,

^cP>0.05 vs group A.