Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats

Table 1 Blood MDA level (nmol/mL erythrocytes) in CCl₄+NaCl-treated (A), CCl₄+UD treated (B), CCl₄+NS treated (C) and CCl₄+UD+NS treated (D) rats (mean±SD)

Groups(d)	A	B	C	D
0	1.23±0.09	1.18±0.14	1.21±0.12	1.25±0.03
60	2.81±0.05	1.35±0.07	1.41±0.09	1.28±0.12

Table 2 Serum antioxidant levels (mg/dL) in CCl₄+NaCl-treated(A), CCl₄+UD treated (B), CCl₄+NS treated (C) and CCl₄+UD+NS treated (D) rats (mean±SD)

Groups(d)	A	B	C	D
GSH
0	50.76±0.72	47.14±1.02	47.72±1.25	49.36±0.93
60	40.21±2.38	55.44±3.32	50.63±3.41	61.12±8.26
Ceruloplasmin
0	18.72±0.82	18.47±0.89	17.36±1.13	19.23±0.59
60	12.92±0.49	29.33±0.64	25.90±1.61	30.22±1.23
Vitamin E
0	0.20±0.12	0.19±0.01	0.18±0.01	0.20±0.13
60	0.11±0.02	0.34±0.03	0.24±0.02	0.45±0.01
Vitamin C
0	0.53±0.01	0.51±0.01	0.52±0.01	0.54±0.01
60	0.40±0.01	0.61±0.02	0.54±0.02	0.89±0.01
Beta-karoten
0	26.49±0.85	25.28±0.44	26.41±0.37	25.15±0.83
60	19.28±1.23	25.21±1.55	26.73±1.53	25.25±1.27
Retinol
0	50.33±0.87	52.72±0.66	51.22±0.39	52.64±0.55
60	44.98±1.18	56.19±0.37	53.52±0.63	61.69±1.69

Table 3 Serum liver enzyme levels (U/L) in CCl4+NaCl-treated (A), CCl4+UD treated (B), CCl4+NS treated (C) and CCl4+UD+NS treated (D) rats (mean±SD)

Groups(d)	A	B	C	D
ALP
0	957±23.62	961±16.64	987±13.64	1028±36.51
60	1354±32.58	692±24.21	637.82±31.21	772.57±91.45
ALT
0	89.3±4.86	78.21±17.35	80.14±20.12	83.17±11.21
60	2762±42.45	553±60.29	425±42.24	253±39.27
AST
0	143.29±6.43	141.28±16.26	143.50±7.85	144.27±20.44
60	2342.25±34.06	554.23±14.83	1031.44±92.68	672.17±58.42

Table 4 Weights (g) of rats in CCl₄+NaCl-treated (A), CCl₄+UD treated (B), CCl₄+NS treated (C) and CCl₄+UD+NS treated (D) rats (mean±SD)

Groups(d)	A	B	C	D
0	189±6.21	181.43±12.21	187.21±4.33	189.63±3.21
60	171.73±3.90	204.02±12.09	214.76±12.72	217.50±11.52