Distinct immune response induced by peptidoglycan derived from Lactobacillus sp

Table 2 Genes related to ubiquitin-dependent protein catabolism

Probe set	Gene symbol	SLR (I)	SLR (II)
1417172_at	Ubce8	2.7	NC
1422462_at	2700084L22Rik	1.7	NC
1452058_a_at	Rnf11	1.6	NC
1426404_a_at	Rnf11	1.1	NC
1454802_x_at	Arih2	1.1	1.1
1450696_at	Psmb9	1.3	NC
1422962_a_at	Psmb8	1	NC
1452402_at	Uchl3	1.5	NC
1449855_s_at	Uchl3	1.4	NC
1423107_at	Ube2b	1.1	NC
1454036_a_at	Usp15	1.2	NC
1450037_at	Usp9x	NC	1
1418191_at	Usp18	NC	2.1
1448420_a_at	Fbxl12	NC	1

Probe set: probe used in Affymetrix GeneChip. NC: change in gene expression is not significant. Minus SLR: gene expression is down-regulated. I: One dose of PG treatment. II: Three doses of PG treatment.

Table 1 Relationship between Lactobacillus PG-induced expression of proteins and pro-inflammatory and anti-inflammatory response

		SLR				SLR
Probe set	Gene symbol	I	II	Probe set	Gene symbol	I	II
1450788_at	Amyloid A1	NC	1.1	1419282_at	Ccl12	–2.1	NC
1449326_x_at	Amyloid A2	–2.1	1.8	1420380_at	Ccl2	–4	NC
1450826_a_at	Amyloid A3	–2.4	NC	1417925_at	Ccl22	–1.2	0.5
1448162_at	Vcam1	2	1.6	1450488_at	Ccl24	–3.2	NC
1448862_at	Icam2	1.5	1.7	1421228_at	Ccl7	–4.3	0.6
1422930_at	Icam4	1.8	NC	1419684_at	Ccl8	–2.5	–1.3
1435290_x_at	H2-Aa	2	0.6	1417936_at	Ccl9	–1.6	NC
1451721_a_at	H2-Ab1	1.7	0.6	1419209_at	Cxcl1	NC	2.6
1422527_at	H2-DMa	1.4	0.6	1418930_at	Cxcl10	NC	3.6
1419744_at	H2-DMb1	1.6	0.6	1419697_at	Cxcl11	NC	4.5
1422891_at	H2-Ea	2.1	0.6	1417851_at	Cxcl13	NC	2.9
1417025_at	H2-Eb1	1.6	0.6	1449984_at	Cxcl2	NC	1.1
1419297_at	H2-Oa	2.4	NC	1418652_at	Cxcl9	NC	2.1
1418536_at	H2-Q7	1.3	0.7	1418480_at	Cxcl7	NC	–1.9
1449875_s_at	H2-T10	1.6	0.7	1418457_at	Cxcl14	–6.9	–1.3
1449556_at	H2-T23	1.2	0.7	1449195_s_at	Cxcl16	–1.1	NC
1422160_at	H2-T24	NC	0.6	1448995_at	Cxcl4	–1.5	NC
1452544_x_at	H2-K	NC	0.5	1419600_at	Defb4	–1.2	NC
1450534_x_at	H2-Q1	NC	0.5	1420653_at	Tgfb1	–2.2	0.6
1417314_at	H2-Bf	NC	1	1417455_at	Tgfb3	–2.5	NC
1426324_at	H2-D1	NC	1.1	1425947_at	Ifng	NC	0.9
1419413_at	Ccl17	1.5	1.7	1450330_at	Il10	NC	1.4
1419426_s_at	Ccl21a	3.8	NC	1418219_at	Il15	NC	3.5
1419561_at	Ccl3	2.6	1.9	1417268_at	Cd14	1.2	NC
1421578_at	Ccl4	2.5	2.4	1419532_at	Il1r2	1.2	NC

Probe set: probe used in Affymetrix GeneChip. NC: change in gene expression is not significant. Minus SLR: gene expression is downregulated. I: One dose of PG treatment. II: Three doses of PG treatment.