In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats

doi:10.3748/wjg.v11.i4.561

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Jan 28, 2005 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2005; 11(4): 561-566
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.561

Table 1 Level of liver index in each group of rats (mean±SD).

Group	n	Liver index	Urinary excretion of Hyp
Control	16	0.0249±0.0027	47.80±5.76
Hepatic fibrosis	12	0.0423±0.0044^a	62.00±6.40^b
Non-DSHX-treated	10	0.0295±0.0019^c	82.44±30.83^b
DSHX-treated	10	0.0267±0.0017^c	541.09±73.39^d^f

^aP<0.05,

^bP<0.01 vs normal control group;

^cP<0.05,

^dP<0.01 vs hepatic fibrosis group;

^fP<0.01 vs non-DSHX-treated group.

Table 2 Concentrations of serum HA and ALT in each group of rats (mean±SD).

Group	n	HA (ng/mL)	ALT (U/L)
Control	16	192.52±41.97	32.40±2.30
Hepatic fibrosis	12	316.17±78.48^a	174.50±6.02^b
Non-DSHX-treated	10	300.86±72.73^a	104.75±6.54^b^d
DSHX-treated	10	200.78±31.71^c^e	93.13±5.79^d^f

^aP<0.05,

^bP<0.01 vs normal control group;

^cP<0.05,

^dP<0.01 vs hepatic fibrosis group;

^eP<0.05,

^fP<0.01 vs non-DSHX-treated group.

Table 3 Degree of hepatic fibrosis in each group of rats.

Group	n	Degree of hepatic fibrosis
Group	n	0	I	II	III	IV	V	Average
Control	16	16	0	0	0	0	0	0
Hepatic fibrosis	12	0	0	0	1	7	4	4.25^b
Non-DSHX-treated	10	0	1	4	3	2	0	2.60^b^d
DSHX-treated	10	1	6	2	1	0	0	1.30^d^f

^bP<0.01 vs normal control group;

^dP<0.01 vs hepatic fibrosis group;

^fP<0.01 vs non-DSHX-treated group.

Table 4 Percentages of expression of COL I and III in livers of rats in each group (mean±SD).

Group	n	COL I (%)	COL III (%)
Control	16	0.47±0.05	0.40±0.03
Hepatic fibrosis	12	4.18±2.26^b	3.04±0.62^b
Non-DSHX-treated	10	3.22±1.44^b	2.23±0.58^b^c
DSHX-treated	10	1.07±0.96^d^f	1.09±0.58^d^f

^bP<0.01 vs normal control group;

^cP<0.05,

^dP<0.01 vs hepatic fibrosis group;

^fP<0.01 vs non-DSHX-treated group.

Table 5 Apoptosis index and cell cycles detected by flow cytometry in each group of rats (mean±SD).

Group	n	AI (%)	Go-G1 (%)	S-phase (%)	G2-M (%)
Control	3	0.28±0.05	68.40±6.47	1.82±0.33	29.76±6.80
Hepatic fibrosis	3	1.63±0.25^a	62.27±17.96	9.83±1.81^a	23.26±10.95
Non-DSHX-treated	3	1.78±0.43^a	50.53±2.25	11.87±1.92^a	13.60±1.15
DSHX-treated	3	7.81±0.47^c^e	94.30±1.33^c^e	3.11±1.27^c^e	2.58±0.73^d^f

^aP<0.05 vs normal control group;

^cP<0.05,

^dP<0.01 vs hepatic fibrosis group;

^eP<0.05 ,

^fP<0.01 vs non-DSHX-treated group.

Citation: Geng XX, Yang Q, Xie RJ, Luo XH, Han B, Ma L, Li CX, Cheng ML. In vivo effects of Chinese herbal recipe, Danshaohuaxian, on apoptosis and proliferation of hepatic stellate cells in hepatic fibrotic rats. World J Gastroenterol 2005; 11(4): 561-566
URL: https://www.wjgnet.com/1007-9327/full/v11/i4/561.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i4.561