Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity

Table 1 Demographic data of the patients

	Ala-Gln group			Conv group
	All patients	APACHE ≤ 6	APACHE > 6	All patients	APACHE ≤ 6	APACHE > 6
Age (years)	66.7 ± 9.0	61.7 ± 11.2	70.1 ± 6.0	67.6 ± 8.4	64.5 ± 7.6	70.6 ± 8.7
Weight (kg)	56.9 ± 9.1	57.7 ± 8.6	56.3 ± 10.1	57.6 ± 10.3	55.3 ± 8.6	59.8 ± 12.0
Height (cm)	157.8 ± 6.4	160.4 ± 6.7	156.0 ± 6.1	160.1 ± 8.3	158.8 ± 8.0	161.3 ± 9.0
Male/Female	14/11	4/6	10/5	14/9	6/5	8/4
Diagnosis:
Gastric Ca	18	6	12	14	6	8
Pancreas Ca	4	3	1	4	2	2
Colon Ca	1	0	1	3	2	1
Hepatoma	1	1	0	1	1	0
Duodenal Ca	0	0	0	1	0	1
Rectal Ca	1	0	1	0	0	0

Table 2 Plasma IL-6 concentrations on d 1 postoperatively and on d 6 after TPN administration

	Conv (pg/mL)	Ala-Gln (pg/mL)
All patients	(23)	(25)
Day 11	38.8 ± 31.5	52.5 ± 48.7
Day 6	12.4 ± 12.1a	7.9 ± 5.9 a
APACHE II ≤ 6	(11)	(10)
Day 1	31.2 ± 21.8	37.1 ± 35.4
Day 6	11.9 ± 10.5 a	3.2 ± 1.9 a,b
APACHE II > 6	(12)	(15)
Day 1	45.1 ± 41.7	59.8 ± 53.4
Day 6	12.9 ± 14.8 a	16.1 ± 17.2 a

¹D 1 represents the data obtained after TPN administration. Figures in parentheses indicate number of patients. aP<0.05 vs d 1 after Surgery. bP = 0.029 from Conv group D 6 in APACHE II ≤ 6.

Table 3 Plasma IL-8 concentrations on d 1 postoperatively and on d 6 after TPN administration

	Conv (pg/mL)	Ala-Gln (pg/mL)
All patients	(23)	(25)
Day 11	18.9 ± 8.4	37.6 ± 46.1
Day 6	28.3 ± 22.4	64.6 ± 62.8
APACHE II ≤ 6	(11)	(10)
Day 1	19.4 ± 9.9	15.6 ± 9.0
Day 6	36.9 ± 45.9	24.5 ± 8.9
APACHE II > 6	(12)	(15)
Day 1	18.5 ± 7.3	48.4 ± 52.3
Day 6	31.0 ± 30.4	81.3 ± 67.9

¹D 1 represents the data obtained before TPN administration. Figures in parentheses indicate number of patients.

Table 4 Correlation between plasma IL-6 concentrations and cumulative nitrogen balance postoperatively

	r	P
Total patients (38)	-0.2092	0.249
Ala-Gln group (20)	-0.6608	0.027 a
Conv group (18)	0.033	0.919

^aP<0.05 using pearson's correlation.