CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

Table 1 Age, sex, and alcohol consumption in the different groups

Groups (n)	Alcohol consumption
	Age (yr)	Sex (M/F)	Daily (g)	Duration (yr)
Alcoholic cirrhosis (100)	50.5+12.9	Mar-97	189+119	25.8+11.6
Alcoholic pancreatitis (100)	40.2+11.7	May-95	143+93	15.8+8.8
Alcoholic esophageal Ca (82)	64.4+12.7	82/0	200+175	35.8+13.8
Alcoholic AVN (53)	44.7+9.7	53/0	197+139	19.6+8.2
Non-alcoholic pancreatitis (77)	53.2+17.5	38/39	–	–
Non-alcoholic controls (117)	60.6+18.3	75/32	–	–

Table 2 CD14 polymorphism

Groups (n)	CC	CT	TT	*C	*T
Alcoholic pancreatitis (100)	59cdfh23	39	2	0.79ab	0.21
Alcoholic cirrhosis (100)	46i	49	5	0.711	0.29
Alcoholic esophageal Ca. (82)	25	49	8	0.60	0.40
Alcoholic AVN (53)	18	33	2	0.65	0.35
Non-alcoholic pancreatitis (77)	25	43	9	0.60	0.40
Non-alcoholic controls (117)	49	62	6	0.68	0.32

C allele frequency,

^aP<0.025 vs alcoholic AVN and non-alcoholic controls;

^bP<0.001 vs esophageal carcinoma and non-alcoholic pancreatitis; ¹P=0.055 vs esophageal carcinoma.Genotype CC vs TT,

^cP<0.005 vs esophageal cancer and non-alcoholic pancreatitis;

^dP<0.001 vs alcoholic AVN.Genotype CC vs CT and TT (T– vs T+),

^fP<0.001 vs alcoholic esophageal cancer;

^hP<0.001 vs non-alcoholic pancreatitis;

²P=0.005 vs alcoholic AVN;

³P=0.017 vs non-alcoholic controls. Genotype CC vs CT and TT (T– vs T+),

ⁱP<0.05 vs alcoholic esophageal cancer.

Table 3 CD14 polymorphism in ALDH2 1-1 homozygotes

Group (n)	CC	CT	TT	*C	*T
Alcoholic pancreatitis (65)	41gikm	24	0	0.82a,b,c,e	0.18
Alcoholic cirrhosis (77)	33	40	4	0.69	0.31
Alcoholic esophageal Ca (23)	8	12	3	0.61	0.39
Alcoholic AVN (42)	14	26	2	0.64	0.36
Non-alcoholic pancreatitis (40)	13	21	6	0.59	0.41
Non-alcoholic controls (54)	22	30	2	0.69	0.31

C allele frequency, ^aP<0.025 vs alcoholic cirrhosis; ^bP<0.001 vs non-alcoholic pancreatitis; ^cP<0.05 vs non-alcoholic controls;^eP<0.01 vs esophageal cancer and alcoholic AVN.Genotype CC vs CT and TT,

^gP<0.05 vs alcoholic cirrhosis and alcoholic esophageal cancer;

ⁱP<0.025 vs alcoholic AVN;

^kP<0.005 vs non-alcoholic pancreatitis;

^mP<0.05 vs non-alcoholic controls.

Table 4 CD14 polymorphism in alcoholic patients with and without pancreatitis

Group (n)	CC	CT	TT	*C	*T
Alcoholics without pancreatitis (235)	89cd	131	15	0.66a	0.34
Alcoholics with pancreatitis (100)	59	39	2	0.79	0.21
Alcoholics with genotype ALDH2 1-1
Alcoholics without pancreatitis (142)	59gi	78	9	0.66e	0.34
Alcoholics with pancreatitis (65)	41	24	0	0.82	0.18

C allele frequency,

^aP<0.005 vs alcoholics with pancreatitis.Genotype CC vs TT,

^cP<0.05 vs alcoholics with pancreatitis.Genotype CC vs CT and TT (T– vs T+),

^dP<0.001 vs alcoholics with pancreatitis.C allele frequency,

^eP<0.005 vsalcoholics with pancreatitis.Genotype CC vs TT,

^gP<0.05 vs alcoholics with pancreatitis.Genotype CC vs CT and TT (T– vs T+),

ⁱP<0.005 vs alcoholics with pancreatitis.Edited by Helen