Overexpression of decoy receptor 3 in hepatocellular carcinoma and its association with resistance to Fas ligand-mediated apoptosis

Table 1 Relationship between DcR3 mRNA expression and clinical and pathological features of HCC (n=48)

Features	n	DcR3 mRNA expression(%)	p
Size of mass
≤ 5 cm	17	41.2 (7/17)	<0.05
> 5 cm	31	71.0 (22/31)
Number of node
Single	32	53.1 (17/32)	>0.05
Multiple	16	75 (12/16)
Membrane of the mass
Intact	14	50 (7/14)	>0.05
Not intact	34	64.7 (22/34)
Cancer embolus
Negative	38	60.5 (23/38)	>0.05
Positive	10	60 (6/10)
TNM stage
Stage I,II	20	40 (8/20)	<0.05
Stage III,IV	28	75 (21/28)
Infiltration or metastasis
Negative	35	51.4 (18/35)	<0.05
Positive	13	84.6 (11/13)

Table 2 Survival rate of hepatoma cells cultured in chemicals with different concentration (mean±SE)

	ADM	p	MMC	p	GENZAR	p
4×	51±0.2		44.6±0.19		52.2±0.17
1×	72.7±0.18	<0.01	64.8±0.16	<0.01	66.7±0.17	<0.01
0.25×	82.6±0.17		81.8±0.16		77.9±0.18

Table 3 Comparision of hepatoma cell death induced by chemicals between groups with negative and positive DcR3 expression(mean±SE)

	Survival rate of hepatoma cells
	4-fold	p	1-fold	p	0.25-fold	p
ADM
DcR3 negative	41.8±0.18	>0.05	65.9±0.17	>0.05	74.5±0.19	>0.05
DcR3 positive	58.4±0.19		78.1±0.17		89.1±0.12
MMC
DcR3 negative	36.2±0.07	>0.05	58.6±0.12	>0.05	77.9±0.18	>0.05
DcR3 positive	51.3±0.23		69.7±0.18		85±0.15
GENZAR
DcR3 negative	45.7±0.16	0.146	62.8±0.17	0.396	73.1±0.18	0.332
DcR3 positive	57.4±0.16		69.8±0.17		81.8±0.19