Is adiponectin level a predictor of nonalcoholic fatty liver disease in nondiabetic male patients?

Table 1 Demographic, anthropometric, and biochemical measurements in NAFLD and control groups

	NAFLD (n: 35)	Controls (n: 34)	P
Age (yr)	39.1±7.8	36.1±6.0	NS
Gender (female/male)	20/15	20/14	NS
BMI (kg/m2)	30.5±4.1	23.7±3.8	<0.001
Fasting glucose (mg/dL)	93±9	84±11	<0.01
Total cholesterol (mg/dL)	209±35	186±36	<0.01
HDL cholesterol (mg/dL)	50±12	51±12	NS
LDL cholesterol (mg/dL)	125±28	118±37	NS
Triglycerides (mg/dL)	177±100	103±57	<0.01
AST (IU/L)	36±10	18±5	<0.001
ALT (IU/L)	49±17	18±9	<0.001
GGT (IU/L)	43±16	16±8	<0.001

NS, nonsignificant.

Table 2 Comparison of IR parameters in NAFLD and control groups

	NAFLD (N: 35)	Controls (N: 34)	P
Fasting insulin (IU/L)	14.6±6.7	9.9±4.5	<0.01
Insulin 60 min (IU/L)	99.6±63.1	62.4±43.2	<0.01
Insulin 120 min (IU/L)	65.3±49	40.2±31.9	<0.01
HOMA index	3.3±1.5	2.1±1.1	<0.001
Proinsulin (pmol/L)	10.6±6.4	6.2±4.5	<0.001
C-peptide (ng/mL)	2.7±0.7	2.0±0.6	<0.001
Adiponectin (mg/mL)	8.14±3.4	12.41±9.4	<0.01

Table 3 Regression model of adiponectin as a dependent variable

Independent variables	T	Significance
Gender (male)	–2.791	0.009
Age (yr)	0.774	NS
BMI (kg/m2)	–0.523	NS

NS, nonsignificant.

Table 4 Comparison of male and female patients in both NAFLD and control groups

	Female (N: 40)	Male (N: 29)	P
Age (yr)	37.0±7.1	38.6±7.1	NS
BMI (kg/m2)	27.5±5.8	26.9±4.5	NS
HOMA	2.6±1.4	2.8±1.4	NS
Adiponectin (mg/mL)	11.7±8.9	8.2±3.3	0.025

NS, nonsignificant.

Table 5 Regression model of NAFLD as a dependent variable in males

Independent variables	B	Exp (B)	Significance
Adiponectin (mg/mL)	0.466	1.593	0.045
Age (yr)	–0.086	0.918	NS
BMI (kg/m2)	–0.237	0.789	NS
HOMA	–0.068	0.934	NS

NS, nonsignificant.

Table 6 Regression model of NAFLD as a dependent variable in females

Independent variables	B	Exp (B)	Significance
BMI (kg/m2)	–0.505	0.972	0.007
Age (yr)	–0.028	0.604	NS
HOMA	–0.097	0.908	NS
Adiponectin (mg/mL)	0.003	1.003	NS

NS, nonsignificant.