Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats

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Oct 7, 2005 (publication date) through Dec 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Oct 7, 2005; 11(37): 5853-5858
Published online Oct 7, 2005. doi: 10.3748/wjg.v11.i37.5853

Table 1 Gastric juice-aggravated various gastric biochemical parameters in stomachs of normal, DM and BQC fed DM rats

	Acid ack-diffusionμmol/stomach	Glutathioneμmol/gtissue	Lipid peroxidenmol MDA/gtissue	Mucusμg/gtissue	Hemoglobinmg/stomach	Ulcer areamm²/stomach
Normal saline
Control	8.6±1.2	3.8±0.4	45.6±4.2v	230.2±18.4	0.2±0.2	1.4±0.6
DM	5.0±0.8^a	2.4±0.3^a	95.4±5.2^a	186.1±10.2^a	2.2±0.5^a	64.6±8.5^a
BQC+DM	3.2±0.2^a	1.6±0.2^a	32±11.4^a	155.0±14.8^a	4.6±0.6 ^a	54.8±18.4 ^a
Gastric juice
Control	-164.2±5.4	3.4±0.2	54.0±7.8	220.0±14.5	0.6±0.2b	2.2±1.2
DM	-235.4±10.6^a^c	2.8±0.1^a^c	120.0±10.2^a^c	140.0±12.6^a^c	5.3±0.7^a^c	264.8±27.1^a^c
BQC+DM	-384.2±18.6^a^c	0.8±0.1^a^c	184.0±16.3^a^c	75.0±6.8^a^c	9.0±1.2^a^c	78.6±45.6^a^c

Data are mean±SE (n = 8).

^aP < 0.05 vs corresponding control group.

^cP < 0.05 vs corresponding group in saline-treatment. MDA = malondialdehyde, BQC = betel quid chewing, DM = diabetes mellitus.

Table 2 Effects of lysozyme chloride on various biochemical parameters in gastric juice-irrigated stomachs of BQC-fed DM rats

	mg/kg	Acid back-diffusionμmol/stomach	Glutathioneμmol/gtissue	Lipid peroxidenmol MD/gtissue	Mucusμg/gtissue	Hemoglobinmg/stomach	Ulcer areamm²/stomach
Control
Saline		-132.0±3.4	3.6±0.3	62.6±7.0	206.4±14.6	0.4±0.2	3.2±0.5
Lysozyme chloride	500	-112.4±5.6^a	4.6±0.5^a	40.4±4.2^a	245.4±16.5^a	0.0±0.0^a	0.0±0.0^a
Indomethacin	5
+ lysozyme chloride	500	-140.0±7.2	2.8±0.3^a	74.5±6.8^a	164.6±14.2	1.0±0.5	5.6±08
BQC+DM
Saline		-365.2±20.4	0.8±0.2	160.4±11.6	83.2±10.2	8.0±0.8	396.8±34.2
Lysozyme chloride	50	-292.0±11.2^a	1.7±0.3^a	132.0±12.5^a	126.6±7.4^a	4.0±0.5^a	306.0±25.2^a
	100	220.2±13.0	2.4±0.3^a	108.4±10.6	182.8±9.2	2.2±0.3	168.6±12.4
	500	-186.8±10.2^a	3.4±0.3^a	74.8±6.2	216.3±16.4	1.7±0.3^a	44.5±6.4
Indomethacin	5
+ lysozyme chloride	500	-308.6±18.8^a	1.5±0.2^a	154.0±12.6^a	140.8±11.5^a	4.8±0.8^a	320.4±30.4^a

Data are mean±SE (n = 8).

^aP < 0.05 vs corresponding saline-group. MDA = malondialdehyde. MDA = malondialdehyde, DM = diabetes mellitus, BQC = betel quid chewing.

Citation: Hung CR. Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats. World J Gastroenterol 2005; 11(37): 5853-5858
URL: https://www.wjgnet.com/1007-9327/full/v11/i37/5853.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i37.5853