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©The Author(s) 2005.
World J Gastroenterol. Sep 28, 2005; 11(36): 5696-5700
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5696
Published online Sep 28, 2005. doi: 10.3748/wjg.v11.i36.5696
Table 1 Characteristics of patients (mean±SD, n)
Parameters | Values |
Sex (male/female) | Mar-33 |
Age (range) | 63.3±9.2 (42-78 yr) |
Histopathology | |
Well-differentiated | 6 |
Moderately differentiated | 23 |
Poorly differentiated | 7 |
Stage (UICC) | |
I | 4 |
II | 7 |
III | 18 |
IVa | 7 |
Table 2 Relation between immunohistochemical expressions of biological markers and response of esophageal squamous cell car-cinoma to CRT (n)
Markers | Responder | Non-responder | P |
(CR+PR) | (NC+PD) | ||
p53(-) | 14 | 1 | 0.0095 |
p53(+) | 11 | 10 | |
MT (-) | 21 | 5 | 0.019 |
MT (+) | 4 | 6 | |
CDC25B (-) | 7 | 8 | 0.0129 |
CDC25B (+) | 18 | 3 |
Table 3 Relation between expressions of biological markers and response of esophageal squamous cell carcinoma to CRT (n)
Markers | Responder | Non-responder | P |
(CR+PR) | (NC+PD) | ||
Bax (-) | 17 | 8 | 0.799 |
Bax (+) | 8 | 3 | 0.799 |
Bcl-2 (-) | 18 | 8 | 0.836 |
Bcl-2 (+) | 7 | 3 | 0.836 |
Cyclin D1 (-) | 15 | 6 | 0.305 |
Cyclin D1 (+) | 10 | 5 | 0.305 |
VEGF (-) | 10 | 5 | 0.936 |
VEGF (+) | 15 | 6 | 0.936 |
Ki67 (-) | 4 | 1 | 0.586 |
Ki67 (+) | 21 | 10 | 0.586 |
Table 4 Relation between effects of CRT and immunohistochemical staining
Immunoreactivity/response | P | ||||
p53 | - | - | + | + | 0.027 |
CDC25B | + | - | + | - | |
Responder | 9 | 5 | 9 | 2 | |
Non-responder | 0 | 1 | 3 | 7 | |
MT | - | - | + | + | |
0.0305 | |||||
CDC25B | + | - | + | - | |
Responder | 16 | 5 | 2 | 2 | |
Non-responder | 2 | 3 | 1 | 5 |
- Citation: Sunada F, Itabashi M, Ohkura H, Okumura T. p53 negativity, CDC25B positivity, and metallothionein negativity are predictors of a response of esophageal squamous cell carcinoma to chemoradiotherapy. World J Gastroenterol 2005; 11(36): 5696-5700
- URL: https://www.wjgnet.com/1007-9327/full/v11/i36/5696.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i36.5696