Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 21, 2005; 11(35): 5530-5534
Published online Sep 21, 2005. doi: 10.3748/wjg.v11.i35.5530
Published online Sep 21, 2005. doi: 10.3748/wjg.v11.i35.5530
Table 1 Baseline clinical characteristics of study participants with low (< 0.3 mIU/L), normal (0.3–3 mIU/L) and high (> 3 mIU/L) serum TSH levels
Low serum | Normal serum | High serum | |
TSH n = 385 | TSH n = 3321 | TSH n = 43 | |
Age (yr) | 57.2±15.2a | 48.4±16.3 | 51.1±12.7 |
Sex (male) | 218 (56.6%) | 1 723 (51.9%) | 13 (30.2%)a |
Education | |||
<10 yr | 209 (54.6%)a | 1 206 (36.6%) | 14 (32.6%) |
10 yr (Ref.) | 132 (34.5%) | 1 556 (47.2%) | 19 (44.2%) |
>10 yr | 42 (11.0%) | 535 (16.2%) | 10 (23.3%) |
Physical activity | 130 (33.9%)a | 1 445 (43.7%) | 19 (44.2%) |
Current cigarette smoking | |||
Never (Ref.) | 125 (32.6%) | 1 138 (34.4%) | 15 (34.9%) |
Former | 151 (39.4%) | 1 109 (33.5%) | 17 (39.5%) |
Current | 107 (27.9%) | 1 061 (32.1%) | 11 (25.6%) |
Diabetes mellitus | 38 (10.0%) | 269 (8.2%) | 0 |
Body mass index; kg/m² | 27.4±4.5 | 27.1±4.7 | 27.9±4.6 |
Total cholesterol; mg/dL | 221±44 | 223±49 | 240±53a |
mmol/L | 5.71±1.14 | 5.76±1.26 | 6.20±1.38a |
LDL-Cholesterol; mg/dL | 138±41 | 138±45 | 152±50 |
mmol/L | 3.56±1.05 | 3.56±1.18 | 3.92±1.30 |
HDL-Cholesterol; mg/dL | 54±17a | 56±17 | 60±17 |
mmol/L | 1.41±0.44a | 1.45±0.44 | 1.56±0.43 |
Table 2 Prevalence of previous history of cholecystectomy and sonographically detected gallstones among males and females
History of cholecystectomy (%) | Ultrasound diagnosis of gallstones (%) | Total (%) | |
Males | 122 (6.8) | 160 (8.7) | 282 (14.4) |
Females | 257 (16.1) | 198 (12.9) | 455 (25.3) |
All | 379 (11.2) | 358 (10.6) | 737 (19.7) |
Table 3 Sex-specific independent risk factors for cholelithiasis
Males OR (95%CI) | Females (95%CI) | |
Age; yr (Ref. <30) | ||
30-<40 | 4.15 (1.17-14.69) | 1.97 (1.04-3.75) |
40-<50 | 8.32 (2.47-28.03) | 4.67 (2.55-8.52) |
50-<60 | 16.68 (5.04-55.22) | 7.16 (3.85-13.30) |
60-<70 | 28.02 (8.44-93.05) | 13.01 (6.81-24.88) |
≥70 | 40.09 (12.02-133.76) | 19.60 (9.92-38.72) |
Education; yr (Ref. 10) | ||
<10 | 0.88 (0.62-1.26) | 0.93 (0.67-1.30) |
>10 | 0.72 (0.44-1.16) | 0.68 (0.44-1.05) |
Physical activity | 0.96 (0.71-1.29) | 0.78 (0.60-1.02) |
Smoking (Ref. non) | ||
Ex-smoker | 1.15 (0.79-1.68) | 0.73 (0.53-1.01) |
Current smoker | 1.03 (0.66-1.61) | 0.78 (0.56-1.10) |
Diabetes mellitus | 1.37 (0.94-2.01) | 1.10 (0.72-1.71) |
Body mass index; per kg/m² | 1.04 (1.01-1.08) | 1.08 (1.06-1.11) |
LDL cholesterol; per 10 mg/dL | 0.97 (0.94-1.02) | 0.97 (0.94-1.01) |
HDL cholesterol; per 10 mg/dL | 0.87 (0.78-0.97) | 0.87 (0.78-0.97) |
Table 4 The association between serum TSH levels and cholelithiasis according to sex
Regression models | Low (<0.3 mIU/L)OR (95%CI) | Serum TSH normal (0.3–3.0 mIU/L)OR (95%CI) | High (> 0.3 mIU/L)OR (95%CI) | |
Males; | Crude | 1.89 (1.34–2.67)1 | 1.0 (Reference) | 2.90 (0.90–9.49) |
OR | Adjusted for confounding variables2 | 1.40 (0.96–2.02) | 1.0 (Reference) | 3.77 (1.06–13.41)1 |
Females; | Crude | 1.42 (1.01–2.01)1 | 1.0 (Reference) | 1.11 (0.49–2.52) |
OR | Adjusted for confounding variables2 | 0.89 (0.61–1.32) | 1.0 (Reference) | 0.91 (0.38–2.19) |
- Citation: Völzke H, Robinson DM, John U. Association between thyroid function and gallstone disease. World J Gastroenterol 2005; 11(35): 5530-5534
- URL: https://www.wjgnet.com/1007-9327/full/v11/i35/5530.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i35.5530