Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock

Table 1 Morphometric assessment of small Intestine and colon in different time points after shock resuscitation

		Villous height (μm)		Mucosal thickness (μm)
Group		Jejunum	Ileum	Jejunum	Ileum	Colon
Con		310±30	270±22	545±13	482±19	633±58
Exp(h)	0	309±24	271±31	547±23	483±45	651±65
	1	297±29	244±25a	523±18a	445±26a	639±60
	3	278±24a	210±27a	501±27a	420±31a	674±58
	6	264±19a	228±32a	470±31a	394±27a	664±71
	12	252±25a	220±18a	433±19a	380±33a	652±69
	24	231±28a	204±23a	418±28a	364±35a	631±78

Values are mean±SE; n = 5 rats in control group, n = 7 in each experiment group.

^aP<0.05 vs control group.

Table 2 Changes of L/M ratio and LPS at different time points after shock resuscitation

Group		L/M	LPS (EU/mL)
Con		0.029±0.009	0.09±0.021
Exp(h)	0		0.16±0.042a
	1	0.045±0.017a	0.14±0.012a
	3	0.063±0.012c	0.25±0.023a
	6	0.098±0.021c	0.25±0.028a
	12	0.049±0.016a	0.15±0.045a
	24	0.037±0.011	0.11±0.026

Values are mean±SE; n = 5 rats in control group, n = 7 in each experiment group.

^aP<0.05 vs control group;

^cP<0.05 vs 1 h, 12 h group.

Table 3 Goblet cell number in ileum and colonic mucosa in different time points after shock resuscitation

Group		Ileum	Colon
Con		243±13	310 ±19
Exp(h)	0	244±21	259±11a
	1	227±19a	215±9c
	3	203±14c	231±17c
	6	187±15c	243±21c
	12	166±12c	242±16c
	24	157±9c	248±18c

Values are mean±SE; n = 5 rats in the control group, n = 7 rats in each experiment group.

^aP<0.05 vs control group for colon;

^cP<0.05 vs control and the 0 h group for ileum.