Effect of Jianweiyuyang granule on gastric ulcer recurrence and expression of VEGF mRNA in the healing process of gastric ulcer in rats

Table 1 Method of measuring the gastric ulcer index

Area (mm2)	Depth
	<2 mm	>2 mm
0	_	_ (ulcer healing)
1–4	11	2
5–9	2	3
10–14	3	4
15–19	4	5
20–24	5	6
25–29	6	7
30–34	7	8
35–39	8	9
40	9	10

¹1–10 = grade of the ulcer index.

Table 2 Ulcer index and the rate of recurrence (mean±SD)

Group	n	Recurrence	Ulcer index	Ulcer index
	IL-1β	rate	(7 d)	(92 d)
Normal	5	0	0	0
Sham operation	5	0	0	0
Model	10	10%	8.7±0.48	0.12±0.32
Model recurrence	10	90%b	8.7±0.48	6.8±0.48b
Ranitidine	10	80%e	6.3±0.57a	5.8±0.57e
JWYY	10	30%f	3.8±0.86c,d	0.82±0.84f

^aP<0.05 vs the model group; ^bP<0 01 vs the model group; ^cP<0.05, ^dP<0 01 vs the ranitidine group; ^eP>0.05 vs the model recurrence group; ^fP<0.01 vs the ranitidine group.

Table 3 Change of MVD in tissues 7 d later (mean±SD)

Group	n	MVD (7 d)
Normal	5	2.2±0.84
Sham operation	5	2.6±1.14
Model	10	8.8±0.97b
Ranitidine	10	10.4±0.97b,a
JWYY	10	14.0±2.62a,d,f

^aP<0.05 vs the model group; ^bP<0.01 vs the normal and sham operation groups; ³²P<0.01 vs the model group; ^fP<0.01 vs ranitidine group.

Table 4 VEGF mRNA expression in each group (mean±SD)

	VEGF mRNA
Group	n	7 d	92 d
Normal	5	0.190±0.019	0.186±0.028
Sham operation	5	0.188±0.019	0.184±0.028
Model	10	0.642±0.034b	0.188±0.012h
Model recurrence	10		0.794±0.02g
Ranitidine	10	0.790±0.037b,d,f	0.794±0.025h
JWYY	10	0.898±0.046b,d	0.899±0.043h

^bP<0.01 vs the normal and sham operation groups; ^dP<0.01 vs the model group; ^fP<0.01 vs the ranitidine group; ^hP<0.01 vs itself on the 7^th d; gP>0.01 vs itself on the 7^th d.