Effect of Gui Zhi decoction on enteric mucosal immune in mice with collagen-induced arthritis

Table 1 CD4 and CD8 cells in enteric lamina propria

Group	n	CD4 positive	CD8 positive
Control	20	492.7 ± 156.7	446.5 ± 122.5
CIA	20	337.5 ± 101.6a	272.8 ± 165.6a
GZH	20	491.8 ± 58.6c	443.9 ± 58.9c
GZL	20	410.1 ± 131.4	338.4 ± 131.4

^aP<0.05 vs control;

^cP<0.05 vs CIA.

Table 2 sIgA-positive cells in lamina propria

Group	n	sIgA-positive cells
Control	20	607.4 ± 203.45
CIA	20	261.5 ± 50.29c
GZH	20	403.2 ± 157.47ae
GZL	20	367.8 ± 103.4ae

^aP<0.05 vs control;

^cP<0.05 vs control;

^eP<0.05 vs CIA group.

Table 3 CD4 and CD8 cells in periphery

Group	n	CD4 (%)	CD8 (%)
Control	10	48.24 ± 5.071	13.84 ± 2.17
CIA	10	56.86 ± 3.817b	12.59 ± 1.74
GZH	10	41.11 ± 3.886d	8.75 ± 2.259d
GZL	10	43.33 ± 6.046d	9.968 ± 2.2

^bP<0.01 vs control;

^dP<0.01 vs CIA group.

Table 4 Changes of IL-6, IL-1β, and TNF-α in serum

Group	n	IL-6 (ng/mL)	IL-1β (ng/mL)	TNF-α (fmol/mL)
Control	10	0.331 ± 0.027	0.133 ± 0.048	6.528 ± 0.991
CIA	10	0.432 ± 0.064b	0.206 ± 0.034b	7.835 ± 0.992b
GZH	10	0.333 ± 0.033d	0.150 ± 0.027	6.383 ± 1.301d
GZL	10	0.423 ± 0.081	0.177 ± 0.060	6.592 ± 0.500

^bP<0.01 vs control;

^dP<0.01 vs CIA.