Copyright
©The Author(s) 2005.
World J Gastroenterol. Sep 14, 2005; 11(34): 5322-5326
Published online Sep 14, 2005. doi: 10.3748/wjg.v11.i34.5322
Published online Sep 14, 2005. doi: 10.3748/wjg.v11.i34.5322
Table 1 Colorectal cancer patients’ characteristics
Number | |
Sex (M/F) | 27/12 |
Location | |
Sigmoid | 12 |
Rectum | 6 |
Rectosigmoid | 4 |
Cecum | 4 |
Colon ascendens | 3 |
Colon descendens | 1 |
Splenic feature | 2 |
Bauhin’s valve | 1 |
Not specified | 6 |
Table 2 Twenty-three patients received chemotherapy before the liver resection
Type of chemotherapy | Number |
5-FU, LV, oxaliplatin | 7 |
5-FU, LV, CPT-11 | 2 |
5-FU, LV | 5 |
Cetuximab, FOLFIRI | 1 |
Cetuximab, CPT-11 | 1 |
CPT-11 | 1 |
Oxaliplatin, capecitabine, CPT-11 | 1 |
Others | 5 |
Table 3 Positive staining of the adhesion molecules in normal and metastatic liver parenchyma
Normal (%) | Metastatic (%) | |
E-cadherin | 39/39 (100) | 37/38 (97.37) |
β-catenin | 35/39 (89.74) | 36/38 (94.74) |
γ-catenin | 18/39 (46.15) | 25/38 (65.79) |
VEGF | 39/39 (100) | 32/38 (84.21) |
p53 | 0/39 (0) | 25/38 (65.79) |
Table 4 Expression of the adhesion molecules in normal and metastatic liver parenchyma (median and range)
Normal | Metastatic | |||
Chemotherapy (n = 23) | No chemotherapy (n = 16) | Chemotherapy (n = 23) | No chemotherapy (n = 16) | |
E-cadherin | 3 (2-4) | 3 (2-6) | 3 (0-6) | 4 (2-6) |
β-catenin | 3 (0-5) | 3 (0-5) | 6 (0-6) | 5 (0-6) |
γ-catenin | 0 (0-3) | 1 (0-2) | 2 (0-4) | 2 (0-4) |
VEGF | 5 (3-5) | 5 (3-5) | 4 (0-5) | 3 (0-4) |
p53 | 0 (0-0) | 0 (0-0) | 3 (0-6) | 2.5 (0-6) |
Table 5 Percentage of macro- and microvesicular steatosis (median and range)
Chemotherapy (n = 23, %) | No chemotherapy (n = 16, %) | |
Macrovesicular | 10 (0-40) | 10 (0-30) |
Microvesicular | 0 (0-10) | 0 (0-10) |
- Citation: Damme NV, Demetter P, Bock WD, Rottiers M, Praet M, Hemptinne B, Peeters M. Limited influences of chemotherapy on healthy and metastatic liver parenchyma. World J Gastroenterol 2005; 11(34): 5322-5326
- URL: https://www.wjgnet.com/1007-9327/full/v11/i34/5322.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i34.5322