Gene expression in rats with Barrett’s esophagus and esophageal adenocarcinoma induced by gastroduodenoesophageal reflux

Table 1 Different expressions of functional genes in BE and EA

Functional genes	Number	Upregulated	Downregulated
Oncogenes and tumor	23	13	10
suppression genes
Ion channel and transporters	26	13	13
Cell cycle proteins	13	4	9
Extra-pressure reaction proteins	20	8	12
Cell regulatory proteins	15	5	10
Cell apoptosis-related proteins	19	11	8
DNA synthesis, repair,	20	6	14
recombinant factors
DNA binding, transcription factors	23	7	16
Cell receptors	23	7	16
Immunity-related proteins	29	12	17
Cell signal transducing proteins	28	9	19
Metabolism-related proteins	29	17	12
Total	268	112	156

Table 2 Different expressions of some genes in BE and EA

Upregulated	Downregulated
Cathepsin C	Glutathione synthetase
Aminopeptidase M	Lecithin-cholesterol acyltransferase
Arachidonic acid epoxygenase	p55CDC
Tryptophan-2,3-dioxygenase	Heart fatty acid binding protein
Ubiquitin conjugating enzyme	Cell adhesion regulator
Cyclic GMP-stimulated	Selectin, endothelial cell, ligand
phosphodiesterase
Tissue inhibitor of metalloproteinase 1
Betaine-homocysteine methyltransferase
Lysozyme
Complement 4 binding protein, alpha
Insulin-like growth factor binding protein
UDP-glucuronosyltransferase
Tissue inhibitor of metalloproteinase 3
Rat liver aldolase B
Retinoid X receptor gamma
Complement component 9
Rat liver carboxylesterase
Testicular cell adhesion molecule 1