Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis

Table 1 Correlation between clinicopathologic features of gastric cancer and COX-2 expression

Variable	n	COX-2 positive cases (%)	P (χ²)
Histologic type
Differentiated	84	59 (70.2)	0.002 (9.15)
Diffuse	111	54 (48.6)
Depth of invasion
T2	84	47 (60.0)	0.483 (1.46)
T3	88	50 (56.8)
T4	23	16 (69.6)
UICC stage
I	14	6 (42.8)
II	23	11 (47.8)	0.410 (2.88)
III	61	38 (62.3)
IV	97	58 (59.8)
Venous invasion
Negative	80	39 (48.8)	0.030 (4.71)
Positive	115	74 (64.3)
Lymph node metastasis
Negative	20	7 (35.0)	0.028 (4.82)
Positive	175	106 (60.6)
Liver metastasis
Negative	170	93 (54.7)	0.017 (5.72)
Positive	25	20 (80.0)
Peritoneal metastasis
Negative	160	95 (59.4)	0.388 (0.74)
Positive	35	18 (51.4)

Table 2 Multivariate logistic regression analysis of independent risk factors for liver metastasis in 195 gastric cancer patients

Independent risk factor	Relative risk	95%CI	P
Venous invasion
Negative	1
Positive	2.698	1.093–6.660	0.031
COX-2 immunoreactivity
Negative	1
Positive	2.857	1.159–7.041	0.023