Expression of MUC1 and its significance in hepatocellular and cholangiocarcinoma tissue

Table 1 Expression of MUC1 in PLC, cirrhotic, and normal liver tissues

Group	n	Expression of MUC1
		-	+	++
Normal liver	10	10	0	0
Cirrhotic liver	20	16	4	0
PLC	96	22	6	68a

^aP<0.05 vs cirrhotic and normal liver tissues.

Table 2 MUC1 expression and PLC clinical pathology behavior

Clinical pathology	n	MUC1 expression			P
		-	+	++
Histological classification
HCC	59	17	4	38	> 0.05
CC	37	5	2	30
Histological differentiation
Wellac	30	14	2	14	< 0.01
Moderate	40	6	2	32
Poor	26	2	2	22
Lymph node metastasis
Yes	52	5	2	45	< 0.01
No	44	17	4	23
Portal vein embolism
Yes	32	1	2	29	< 0.01
No	64	21	4	39
Size of solid tumor (cm)
<5	49	15	2	32	> 0.05
5	47	7	4	36
Recurrence (3 yr)
Yes	65	9	4	52	< 0.01
No	31	13	2	16

^aP<0.05 vs moderately differentiated HCC.

^cP<0.05 vs poorly differentiated HCC.

Table 3 MUC1 localization in PLC tissues and prognosis of PLC

Clinical pathology	n	MUC1 expression		P
		Membrane	Cytoplasm
Lymph node metastasis
Yes	45	23	22	< 0.05
No	23	17	6
Portal vein embolism
Yes	29	11	18	< 0.01
No	39	29	10
Survival rate (yr)
< 3	50	17	33	< 0.01
3	18	13	5

Table 4 MUC1 expression and post-operation metastasis

MUC1 expression	n	Rate of metastasis (%)
Negative	22	31.8
Weak positive	6	33.3
Strong positiveb	68	67.6

^bP<0.01 vs negative.

Table 5 Positive MUC1 expression in PLC tissues and survival of PLC patients

MUC1 expression	n	Survival rate (%)
		6 mo	12 mo	24 mo	36 mo
Negative	22	86.4	72.7	59.1	50
Weak positivea	6	50	33.3	33.3	33.3
Strong positivea	68	51.5	44.1	29.4	26.4

^aP<0.05 vs negative.