Lipid peroxidation and antioxidant status in colorectal cancer

doi:10.3748/wjg.v11.i3.403

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Jan 21, 2005 (publication date) through Nov 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2005; 11(3): 403-406
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.403

Table 1 Levels of final lipid peroxidation products–malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) in the colorectal cancer and normal colon mucosae (mean±SD).

	Variable	n	Levels of lipid peroxidation products (nmol/g tissue)
	Variable	n	MDA	4-HNE
Histological type/grade of	Adc.G2	60	1.97±0.39^a	0.40±0.08^b
colorectal cancer	Adc.G3	6	2.15±0.44^d	0.44±0.10^d
	Adc.muc	15	2.65±0.48^fⁱ^k	0.44±0.07^fⁱ
Clinical stage of colorectal cancer	II	46	1.7±0.39^a	0.37±0.07^a
	III	29	2.25±0.43^d^g	0.45±0.09^d^g
	IV	6	4.04±0.47^fⁱ^k	0.52±0.11^fⁱ^k
Control (normal colon mucosa)			1.39±0.15	0.29±0.03

^aP<0.05,

^bP<0.001-comparison between Adc G2 or stage II cancers and control group. ^cP<0.05,

^dP<0.001-comparison between Adc G3 or stage III cancers and control group. ^eP<0.05,

^fP<0.001-comparison between mucinous adc or stage IV cancers and control group.

^gP<0.05-comparison between Adc G2 or stage II cancers and Adc G3 or stage III cancers.

ⁱP<0.05-comparison between Adc G2 or stage II cancers and mucinous adc or stage IV cancers.

^kP<0.05-comparison between Adc G3 or stage III cancers and mucinous adc or stage IV cancers.

Table 2 Activity of antioxidative enzymes and levels of non-enzymatic antioxidants in colorectal cancersand normal colon mucosae.

	Variable	n	Activity of antioxidative enzymes (U/g tissue)				Level of non-enzymatic antioxidants (nmol/g tissue)
	Variable	n	Cu, Zn-SOD	CAT	GSH-Px	GSSG-R	GSH	Vit.C	Vit.E
Histological	Adc.G2	60	304±38^b	73±15^a	1892±583^a	759±242^a	151±37	439±85^a	31.9±9.5^a
type/grade of	Adc.G3	6	318±48^d	62±18^c	2005±591^c	795±228^c	143±35	407±92^d	29.7±9.2^c
colorectal cancer	Adc. muc	15	363±72^f,i	40±14^f,i,k	2143±623^f	880±194^f	144±43	398±104^f	33.5±8.5^e
Clinical stage of	II	46	237±42^b	76±14^a	1854±552^a	737±228^a	174±36^a	458±88^a	33.1±9.1^a
colorectal cancer	III	29	289±47^d,g	57±16^c,g	1987±699^c	824±236^c	156±39^c	399±90^d,g	29.1±9.4^c
	IV	6	421±58^f,i,k	33±18^f,i,k	2467±368^f,i	951±243^f,i	150±48^e	325±92^f,i	13.3±10.3^f,i,k
Control (normal colon mucosa)			117±25	84±17	1723±189	625±112	167±15	513±64	37.5±5.2

Statistical differences: see Table 1.

Citation: Skrzydlewska E, Sulkowski S, Koda M, Zalewski B, Kanczuga-Koda L, Sulkowska M. Lipid peroxidation and antioxidant status in colorectal cancer. World J Gastroenterol 2005; 11(3): 403-406
URL: https://www.wjgnet.com/1007-9327/full/v11/i3/403.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i3.403