Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations

Table 1 Anthropometric, biochemical, serum iron parameters, liver iron staining and HFE gene mutations in 31 patients with NASH.

	Parameter (n=31)	Reference value	Abnormal-n (%)
1	BMI	<25 kg/m2	23 (74.2)
	I Overweight	25-29	20 (64.5)
	II Obesity	≥30	3 (9.7)
2	W-H ratio (n = 13)		12 (92)
	I. Males (n = 10)	<0.9	10 (100)
	II. Females (n = 3)	<0.85	2 (67)
3	S cholesterol	130-200 mg/dL	13 (41.9)
4	HDL	35-60 mg/dL	8 (25.8)
5	LDL	<130 mg/dL	13 (41.9)
6	S Triglycerides	30-200 mg/dL	10 (32.3)
7	Diabetes		3 (9.7)
8	Impaired glucose tolerance		7 (22.6)
Serum iron parameters (n = 23)
9	Serum iron	65-170 mg/dL	1 (4.3)
10	Transferrin saturation	<55%	1 (4.3)
11	Serum Ferritin	20-250 ng/mL	1 (4.3)
Perls Prussian blue staining on liver biopsy (n = 14)
12	Iron staining positivity	0	10 (71.4)
		1+	3 (21.4)
		2+	1 (7.2)
		3+	0
		4+	0
13	HFE gene mutations (n = 16)
	I. Normal/normal		12 (75)
	II. C282Y/C282Y		0
	III. C282Y /H63D		0
	IV. H63D/ H63D		0
	V. H63D/Normal		4 (25)

Table 2 Grade of iron staining, necroinflammatory grade and stage of fibrosis in liver biopsies of 14 patients with NASH.

Iron grade	Necroinflammatory grade	Fibrosis stage
0	Mild	2
1	Mild	3
0	Mild	3
0	Mild	2
0	Moderate	2
0	Mild	2
0	Mild	2
0	Mild	2
1	Mild	3
0	Mild	0
2	Mild	1
0	Mild	1
0	Mild	2
1	Moderate	2

No association between iron grade and necroinflammatory grade (P = 0.55) and stage of fibrosis (P = 0.09).