Relationship between metabolic enzyme polymorphism and colorectal cancer

doi:10.3748/wjg.v11.i3.331

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jan 21, 2005; 11(3): 331-335
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.331

Table 1 References to colorectal cancer and polymorphisms of metabolic enzymes.

References	Gene and polymor-phism¹	Grouping²	References	Gene and polymor-phism¹	Grouping²
Carcinogenesis. 1991; 12(1): 25-8	1	B	Pharmacogenetics. 1999; 9(2): 165-9	6	B
Carcinogenesis. 1993; 14(9): 1821-4 (abstract)	1	B	Cancer-Res 1995; 55(16): 3537-42	3	B
Carcinogenesis. 1995; 16(7): 1655-7 (abstract)	1,2		Am-J-Epi 1997;145 (abstract)	4
Carcinogenesis. 1996; 17(4): 881-4	1,2	B	Cancer-Res. 1998; 58(15): 3307-11	3,5	B
Carcinogenesis. 1996; 17(9): 1855-9	1,2	B	Int-J-Cancer. 1990; 46(1): 22-30	4	B
Carcino-Terato-Muta 1996; 8(6): 326-332	1	B	Cancer-Res. 1991; 51(8): 2098-100	4	B
Can-Epi-Bio-Prev. 1998; 7(11): 1001-5	1,2	B	Can-Epi-Bio-Prev. 1994; 3(8): 675-82	4
J-Toxicol-Sci. 1998; 23 Suppl 2140-2 (abstract)	1		Cancer. 1994; 74(12): 3108-12	4	B
Can-Epi-Bio-Prev. 1998; 7(12): 1079-84 (abstract)	1,5		Lancet. 1996; 347(9012): 1372-4	4
Zhengjiang Yixueyuan Xuebao 1998; 8(4): 446-447	1	B	Cancer res on prevention and treatment	4	B
			1999; 26(3): 232-233
Cancer-Epidemiol-Biomarkers-Prev. 1999; 8(1): 15-24	1,4	B	Gut. 1997; 41(2): 229-34	5	B
Cancer-Lett. 1999; 142(1): 97-104	1,2	B	Carcinogenesis. 1997l; 18(7): 1351-4	5	B
Exp-Toxicol-Pathol. 1999; 51(4-5): 321-5 (abstract)	1		Carcinogenesis. 1998; 19(1): 37-41	5	B
Can-Epi-Bio-Prev. 1999; 8(4 Pt 1): 289-92	1,2,6	B	Pharmacogenetics. 1998; 8(6): 513-7	5
J-UOEH. 1999; 21(2): 133-47	1,2,3,5,6	B	Cancer-Res. 1996; 56(21): 4862-4	9	B
Jiangshu Linchuangyixue Zazhi 2000; 4(2): 90-91	1,2	B	Cancer-Res. 1997; 57(6): 1098-102	9	B
Anticancer-Res. 2000; 20(1B): 519-22 (abstract)	1		Genet-Test. 1999; 3(2): 233-6	9	B
J-Gast-Hepatol. 2001; 16(6): 631-5 (abstract)	2		Can-Epi-Bio-Prev. 1999; 8(6): 513-8	9
Carcinogenesis. 2001; 22(7): 1053-60	1,2,5,6	B	Can-Epi-Bio-Prev. 1999; 8(9): 825-9	10	B
Gastroenterology 1997: 112: A542 (abstract)	2	B	Can-Epi-Bios-Prev. 2000 ; 9(8): 855-6	7,8	B
			Carcinogenesis. 2001; 88(8): 1323-6	7,8	B

¹Note: 1-GSTM1 deletion, 2-GSTT1 deletion, 3-NAT1*10, 4-NAT2-rapid acetylator phenotype, 5-NAT2-rapid acetylator genotype, 6-GSTP1 lle105Val, 7-CYP1A1 Lle462Val, 8-CYP1A1 MspI*C, 9-METHFR C677T, 10-MTR A2759G

²Note, Grouping B: The literatures in group B, grouping A: The literatures in group B.

Table 2 Results of meta-analysis of polymorphisms and risk for colorectal cancer in group A.

	Study numbers	Cumulative cases	Cumulative controls	Test of heterogeneity		Statistical method	OR	95% CI	Significance P
	Study numbers	Cumulative cases	Cumulative controls	Q	P		OR	95% CI	Significance P
GSTM1 deletion	18	5455	6853	31.1	<0.05	Statistical method	Random	1.08	0.96-1.20	>0.20
GSTT1 deletion	11	1348	1792	29.79	<0.001	Random	1.42^b	1.21-1.66	<0.001
GSTP1 lle105Val	4	612	755	4.06	0.2	Fixed	1.09	0.87-1.37	>0.30
NAT1*10	3	520	433	5.43	0.10-0.20	Fixed	1.25	0.96-1.63	>0.10
NAT2-rapid acetylator p&g	18	6741	8015	22.86	0.20-0.30	Fixed	1.08^a	1.00-1.16	<0.05
NAT2-rapid acetylator p	8	2182	2861	14.24	0.10-0.20	Fixed	1.15^a	1.02-1.31	<0.05
NAT2-rapid acetylator g	10	4559	5154	7.71	>0.50	Fixed	1.05	0.94-1.14	>0.20
CYP1A1 Lle462Val	2	235	280	1.77	>0.30	Fixed	1.26	0.77-2.08	0.05-0.1
CYP1A1 MspI*C	2	234	250	8.36	<0.02	Random	1.3	0.82-2.06	>0.30
METHFR C677T	4	1949	3099	3.11	0.30-0.50	Fixed	0.83	0.68-1.01	>0.10
MTR A2759G	3	613	1 189	0	0.9	Fixed	0.6	0.28-1.29	0.10-0.20

Fixed: Fixed-effect model, Random: Random-effects model.

^aP<0.05,

^bP<0.01.

Table 3 Results of meta-analysis of polymorphisms and risk for colorectal cancer in group B.

Gene and polymorphism	Study numbers	Cumulative cases	Cumulative controls	Test of heterogeneity		Statistical method	OR	95% CI	Significance P
Gene and polymorphism	Study numbers	Cumulative cases	Cumulative controls	χ	P		OR	95% CI	Significance P
GSTM1 deletion	14	3002	3911	20.54	0.08	Statistical method	Fixed	1.07	0.97-1.17	0.2
GSTT1 deletion	8	1029	1492	12.52	0.085	Fixed	1.20^a	1.00-1.44	0.05
GSTP1 lle105Val	4	609	755	3.63	0.3	Fixed	1.08	0.86-1.35	0.5
NAT1*10	3	520	433	5.2	0.07	Fixed	1.2	0.92-1.56	0.18
NAT2-rapid acetylator p&g	12	3121	3697	13.61	0.26	Fixed	1.02	0.92-1.13	0.7
NAT2-rapid acetylator p	6	2038	2546	8.91	0.11	Fixed	1.06	0.94-1.20	0.3
NAT2-rapid acetylator g	6	1083	1151	3.62	0.61	Fixed	0.95	0.79-1.13	0.5
CYP1A1 Lle462Val	2	235	280	1.62	0.2	Fixed	1.17	0.71-1.91	0.5
CYP1A1 MspI*C	2	234	280	5.01	0.03	Random	1.21	0.77-1.90	0.4
METHFR C677T	3	546	1 413	1.38	0.5	Fixed	0.69^a	0.51-0.94	0.02
MTR A2759G	2	356	476	0	0.98	Fixed	0.6	0.28-1.29	0.19

Fixed: Fixed-effect model, Random: Random-effects model.

^aP<0.05.

Citation: Chen K, Jiang QT, He HQ. Relationship between metabolic enzyme polymorphism and colorectal cancer. World J Gastroenterol 2005; 11(3): 331-335
URL: https://www.wjgnet.com/1007-9327/full/v11/i3/331.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i3.331