Clinical characteristics of fulminant hepatitis in pregnancy

Table 1 Laboratory findings of FHP group and FHNP group (mean±SD)

tems	FHP group	FHNP group	t	P
Glutamate–pyruvate transaminase (ALT, U/L)	424.05±285.12	747.04±621.23	1.996	>0.05
Glutamic–oxalacetic transaminase (AST, U/L)	436.92±304.52	534.93±525.73	1.657	>0.05
ALT/AST	0.89±0.96	1.32±1.56	1.201	>0.05
Alkaline phosphatase (ALP, U/L)	199.42±101.02	142.23±50.03	–2.716	<0.05
Total bilirubin (Tbil, μmol/L)	403.11±162.32	460.54±246.45	0.998	>0.05
Direct bilirubin (Dbil, μmol/L)	240.05±111.69	230.44±112.85	–0.316	>0.05
Bile acid (TBA, μmol/L)	105.92±72.17	205.96±37.20	3.053	<0.05
Serum albumin (ALB, g/L)	28.00±4.45	33.49±5.92	3.818	<0.05
Cholesterol (CHOL, mmol/L)	1.70±0.75	1.91±1.00	0.838	>0.05
Cholinephospholipid (CHE, U/L)	3 132.55±983.57	3 885.81±1 510.60	1.49	>0.05
Blood glucose (GLU, mmol/L)	3.03±1.50	5.25±3.82	2.728	<0.05
Blood urea nitrogen (BUN, mmol/L)	9.66±9.07	4.34±4.02	–2.888	<0.05
Creatinine (Cr, mmol/L)	230.99±205.46	60.55±37.47	–4.459	<0.05
Serum calcium (Ca, mmol/L)	2.00±0.24	2.14±0.21	2.1	<0.05
Alpha-fetoprotein (AFP, ng/mL)	186.11±135.74	456.47±1 374.12	0.805	>0.05
Blood ammonia (NH3, μmol/L)	92.05±55.39	127.71±83.30	1.263	>0.05
PT (s)	43.93±43.66	44.10±26.32	0.018	>0.05
PTA (%)	25.33±12.30	20.81±9.44	–1.513	>0.05

Table 2 Comparison of complications between FHP group and FHNP group

Complications	FHP (n = 25, %)	FHNP (n = 30, %)	χ2	P
Peritonitis	14 (56)	13 (43.3)	0.875	>0.05
HE	19 (76)	15 (50.0)	3.905	<0.05
HRS	16 (64)	4 (13.3)	15.128	<0.01
Hemorrhage	14 (56)	1 (3.3)	13.221	<0.01
Pulmonary infection	4 (16)	4 (13.3)	0	>0.05
DIC	6 (24)	0 (0)	5.801	<0.05