Copyright
©The Author(s) 2005.
World J Gastroenterol. Aug 7, 2005; 11(29): 4547-4551
Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4547
Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4547
Table 1 Pharmacokinetic parameters after oral administration of either SM·HCl 24-h test sustained-release pellets or 12-h reference sustained-release tablets in beagle dogs at a single dose of 120 mg/animal (n = 6, mean±SD)
| Parameter | Test formulation | Reference formulation |
| Cmax (ng/mL) | 893.1±119.4 | 1 334.5±150.5 |
| tmax (h) | 9.83±0.40 | 2.67±0.21 |
| Ke (1/h) | 0.044±0.01 | 0.084±0.01 |
| t0.5 (h) | 20.7±8.7 | 8.6±1.9 |
| AUC0–tn (mg·h/L) | 13.50±1.47 | 13.06±9.45 |
| F (%) | 103.41 | - |
- Citation: Sun J, Shi JM, Zhang TH, Gao K, Mao JJ, Li B, Sun YH, He ZG. Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs. World J Gastroenterol 2005; 11(29): 4547-4551
- URL: https://www.wjgnet.com/1007-9327/full/v11/i29/4547.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i29.4547