Mutations outside the YMDD motif in the P protein can also cause DHBV resistant to Lamivudine

Table 1 DHBV quantity in the duck blood of various groups expressed by A_{570 nm} value (mean±SD)

Groups	D0	D5	D10	P3
Lamivudine-susceptive DHBV control	0.96 ± 0.31	1.00 ± 0.06	0.87 ± 0.05	0.87 ± 0.02
LRDHBV control	0.91 ± 0.03	0.86 ± 0.01	0.95 ± 0.01	0.95 ± 0.04
LRDHBV-infected group administrated by large dose Lamivudine	0.96 ± 0.03	0.94 ± 0.02	0.97 ± 0.05	0.97 ± 0.03
LRDHBV-infected group administrated by small dose Lamivudine	0.96 ± 0.02	0.88 ± 0.02	0.87 ± 0.01	0.90 ± 0.05
Lamivudine-susceptive DHBV-infected group administrated by small dose Lamivudine	0.96 ± 0.05	0.73 ± 0.05b	0.22 ± 0.03b	0.69 ± 0.02b

^bP < 0.01 group A vs group E.