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©The Author(s) 2005.
World J Gastroenterol. Jul 7, 2005; 11(25): 3860-3865
Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3860
Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3860
Table 1 Detection of NF-κB and AP-1 in HCC
Group | Cases | NF-κB | AP-1 |
nucleus/cytoplasm | nucleus/cytoplasm | ||
+ nucleus (+) (%) | + nucleus (+) (%) | ||
Tumor tissue | 40 | 22 (55)a | 24 (60) |
Well differentiated | 25 | 13 (52) | 14 (56) |
Poorly differentiated | 15 | 9 (60) | 10 (66.7) |
Nontumor tissue | 40 | 7 (17.5) | 4 (10) |
Normal tissue | 7 | 0 | 0 |
Table 2 Expression of Fas, FasL, ICH-1L, and ICH-1S in HCC
Table 3 Relationship between activated NF-κB and apoptosis proteins in HCC
NF-κB | Cases | Apoptosis protein | |||||||
Fas | FasL | ICH-1L | ICH-1S | ||||||
+ | – | + | – | + | – | + | – | ||
Activated | 22 | 6 | 16 | 5 | 17 | 13 | 12 | 17 | 8 |
Inactivated | 18 | 1 | 17 | 1 | 17 | 2 | 13 | 4 | 11 |
χ2 | 1.9048 | 1.4495 | 4.4444 | 4.8722 | |||||
P | > 0.05 | > 0.05 | < 0.05 | < 0.05 |
Table 4 Relationship between activated AP-1 and apoptosis proteins in HCC
AP-1 | Cases | Apoptosis protein | |||||||
Fas | Fas L | ICH-1L | ICH-1S | ||||||
+ | – | + | – | + | – | + | – | ||
Activated | 25 | 7 | 18 | 6 | 19 | 13 | 12 | 16 | 9 |
Inactivated | 15 | 0 | 15 | 0 | 15 | 2 | 13 | 3 | 12 |
χ2 | 3.3362 | 2.5621 | 4.4444 | 5.6207 | |||||
P | > 0.05 | > 0.05 | < 0.05 | < 0.025 |
Table 5 Relationship between activated NF-κB and apoptosis proteins in nontumor tissues
NF-κB | Cases | Adjacent nontumor tissues | ICH-1S | Cases | Normal liver tissues | |||||||||||||
Fas | FasL | ICH-1L | Fas | FasL | ICH-1L | ICH-1S | ||||||||||||
+ | – | + | – | + | – | + | – | + | – | + | – | + | – | + | – | |||
Activated | 7 | 15 | 7 | 13 | 9 | 19 | 3 | 21 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inactivated | 33 | 6 | 12 | 5 | 13 | 10 | 8 | 10 | 8 | 7 | 0 | 7 | 0 | 7 | 2 | 5 | 1 | 6 |
χ2 | 4.8211 | 3.9221 | 4.7130 | 6.8946 | 0 | 0 | 0 | 0 | ||||||||||
P | < 0.05 | < 0.05 | < 0.05 | < 0.05 | > 0.05 | > 0.05 | > 0.05 | > 0.05 |
- Citation: Guo LL, Xiao S, Guo Y. Activation of transcription factors NF-kappaB and AP-1 and their relations with apoptosis-associated proteins in hepatocellular carcinoma. World J Gastroenterol 2005; 11(25): 3860-3865
- URL: https://www.wjgnet.com/1007-9327/full/v11/i25/3860.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i25.3860