Zhu H, Chen XP, Zhang WG, Luo SF, Zhang BX. Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma. World J Gastroenterol 2005; 11(25): 3855-3859 [PMID: 15991282 DOI: 10.3748/wjg.v11.i25.3855]
Corresponding Author of This Article
Dr. Hong Zhu, Hepatic Surgery Center, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Dadao, Wuhan 430030, Hubei Province, China. hong_jasmine@hotmail.com
Article-Type of This Article
Liver Cancer
Open-Access Policy of This Article
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World J Gastroenterol. Jul 7, 2005; 11(25): 3855-3859 Published online Jul 7, 2005. doi: 10.3748/wjg.v11.i25.3855
Table 1 Relationship of the expression of survivin and clinicopatho-logical factors of HCC
n
Survivin
P
Positive (n)
Percent (%)
Tissue
< 0.01
Cirrhosis
38
3
7.9
HCC
38
23
60.5
Age (yr)
> 0.05
< 60
31
19
61.3
≥ 60
7
4
57.1
Sex
> 0.05
Male
33
21
63.6
Female
5
2
40
Size (cm)
> 0.05
≥ 5
17
12
70.6
< 5
21
11
52.4
Differentiation
> 0.05
Moderate to well
16
9
56.3
Poor
22
14
63.6
Metastasis
< 0.05
Positive
14
12
85.7
Negative
24
11
45.8
Table 2 Expression of survivin and VEGF protein in HCC tissues
VEGF
P
Positive
Negative
Survivin
<0.01
Positive
18
5
Negative
3
12
Table 3 Coincident expression of survivin and VEGF protein in HCC or liver cirrhosis tissues
HCC group
Cirrhosis group
P
(n = 38)
(n = 38)
Survivin
3229.3 ± 1383.2
562.6 ± 226.5
< 0.01
VEGF
1134.8 ± 862.2
445.4 ± 322.6
Table 4 Correlation between HCC metastasis and expression of survivin and VEGF protein
Metastasis group
Non-metastasis group
P
(n = 14)
(n = 24)
Survivin
3841.4 ± 1061.2
1253.8 ± 725.3
< 0.01
VEGF
1388.6 ± 652.4
1081.3 ± 773.5
< 0.01
Citation: Zhu H, Chen XP, Zhang WG, Luo SF, Zhang BX. Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma. World J Gastroenterol 2005; 11(25): 3855-3859