Anti-cancer effect of iNOS inhibitor and its correlation with angiogenesis in gastric cancer

Table 1 Inhibitory effects of AG on transplanted stomach cancer in mice (n = 10, mean±SD)

Group	Concentration of NO	Weight of tumor (g)	Inhibition rate (%)
	in plasma (μmol/L)
Control	46.6 ± 2.3	1.7 ± 0.5	-
MMC	42.1 ± 2.3	1.0 ± 0.2b	41.2
AGL	17.3 ± 2.0b	1.1 ± 0.3a	35.3
AGH	12.9 ± 2.0b	0.9 ± 0.3b	47.1
MMC+AGH	12.7 ± 2.1b	0.8 ± 0.2b	52.9

^aP < 0.05,

^bP < 0.01 vs control group.

Table 2 Effects of AG on the microvessel density, the expression of iNOS and VEGF in tumor (n = 10, mean±SD)

Group	iNOS	VEGF	MVD
Control	11.3 ± 1.3	10.3 ± 1.6	68.3 ± 10.6
MMC	9.3 ± 1.8a	8.9 ± 2.1	56.9 ± 10.3
AGL	7.1 ± 1.7a	7.6 ± 1.2a	44.4 ± 16.5a
AGH	3.8 ± 0.9b	4.8 ± 1.6b	21.2 ± 12.4b
MMC+AGH	2.4 ± 1.1b	2.1 ± 1.4b	8.8 ± 2.6b

^aP < 0.05,

^bP < 0.01 vs control group.