Relation of CagA seropositivity to cagPAI phenotype and histological grade of gastritis in patients with Helicobacter pylori infection

Table 1 CagA serology and bacterial phenotypes.

	cagA		cagE and VirD4
	Positive	Negative	Positive	Negative
ELISA Positive	33	23	31	23
Negative	0	4	2	4
Accuracy (%)	61.7		58.3
Immunoblot Positive	44	12	43	11
Negative	2	2	3	3
Accuracy (%)	76.7		76.7

Table 2 CagA serology in seven patients with H pylori without intact cagPAI.

(Age, sex)	cagPAI		Serology
	cagA	cagE and VirD4	ELISA	Immunoblot
Patient A (73, F)	Positive	Negative	Positive	Positive
Patient B (83, M)	Positive	Negative	Positive	Positive
Patient C (74, F)	Positive	Negative	Negative	Negative
Patient D (64, F)	Negative	Positive	Negative	Positive
Patient E (62, F)	Negative	Negative	Negative	Positive
Patient F (51, F)	Negative	Negative	Negative	Negative
Patient G (69, M)	Negative	Negative	Negative	Negative

Table 3 Grade of gastritis in CagA seropositive and negative patients.

	Grade	ELISA		Western blot
		Positive	Negative	Positive	Negative
Antrum MNCa	0	0	0	0	0
	1	4	4	4	4
	2	19	17	30	6
	3	9	2	10	1
PMN	0	9	8	13	4
	1	17	13	23	7
	2	6	2	8	0
	3	0	0	0	0
H pylori	0	1	2	2	1
	1	14	7	17	4
	2	7	6	11	2
	3	10	8	14	4
Atrophy	0	4	4	4	4
	1	11	2	12	1
	2	9	11	16	4
	3	8	6	12	2
Corpus MNCb	0	1	2	1	2
	1	3	4	4	3
	2	23	14	31	6
	3	5	3	8	0
PMN	0	6	6	7	5
	1	20	12	28	4
	2	6	5	9	2
	3	0	0	0	0
H pylori	0	1	2	3	0
	1	8	6	10	4
	2	5	7	8	4
	3	18	8	23	3
Atrophy	0	4	2	5	1
	1	13	11	20	4
	2	10	5	14	1
	3	5	5	5	5

MNC, mononuclear cells; PMN, polymorphonuclear cells. Histological grades are 0: none, 1: mild, 2: moderate, and 3: marked.

^aP<0.05,

^bP<0.01 (when seropositivity was defined by Western blot).