Hepatosplenic γδ T-cell lymphoma

Table 1 Clinical features of hepatosplenic γδ T-cell lymphoma in eight Chinese patients.

CaseNumber	Sex	Age (yr)	Clinical symptoms	ALT <40(U/L)	ALP 27-107 (U/L)	g-GT 10-50 (U/L)	LDH 97-270 (U/L)	Platelet count 100-350 ×109/L	Hemoglobin >110 (G/L)
1	M	12	Fever, weight loss, hepatosplenomegaly, died 4 mo after diagnosis	199	239	NE	899	104	79
2	M	22	Fever, hepatosplenomegaly	NE	NE	NE	NE	NE	NE
3	M	25	Fever, weight loss, hepatosplenomegaly, jaundice, died 1 mo after diagnosis	775	563	214	775	88	103
4	F	28	Fever, hepatosplenomegaly abdominal pain	55	246	66	Normal	108	100
5	M	30	Fever, weight loss, hepatosplenomegaly	71	506	169	358	49	95
6	F	30	Fever, weight loss, hepatosplenomegaly, abdominal pain	155	500	115	518	74	91
7	M	36	Fever, weight loss, hepatosplenomegaly, jaundice; died 4 mo after diagnosis	409	350	121	389	90	143
8	M	52	Fever, weight loss, hepatosplenomegaly, abdominal pain, jaundice	Normal	159	82	Normal	64	107

NE, not evaluable; normal, within the normal range.

Table 2 Pathological features of hepatosplenic γδ T-cell lymphoma in eight Chinese patients.

Case No.	Spleen weight (g)	Gross appearance (cut surface) of spleen	Microscopical findings	Lymphoid involvement	Bone marrow involvement
1	910	Homogeneous red-purple, no nodule, soft	Lymphoma cells infiltrate liver sinus, splenic sinusoids; liver portal tract, liver fatty degeneration	NO	NO
2	800	Homogeneous dull-red, firm	Lymphoma cells infiltrate liver sinus, splenic sinusoids	NE	NE
3	Part of accessory spleen	Homogeneous gray-red, firm	Lymphoma cells infiltrate liver sinus, splenic sinusoids; liver fatty degeneration	NO	NO
4	445 (body weight 45 kg)	Homogeneous gray-red, no nodule	Lymphoma cells infiltrate liver sinus, splenic sinusoids	NO	NO
5	1155	Homogeneous gray-red, firm	Lymphoma cells infiltrate liver sinus, splenic sinusoids; liver fatty degeneration	Mediastinal lymphadenopathy	NO
6	800	Homogeneous gray-red, soft	Lymphoma cells infiltrate liver sinus, splenic sinusoids; liver portal tract, liver fatty degeneration	NO	NO
7	810	Homogeneous dull-brown, no nodule	Lymphoma cells infiltrate liver sinus, splenic sinusoids; liver portal tract, liver fatty degeneration	NO	Suspected lymphoid cell
8	480 (body weight 45 kg)	Homogeneous dull-red, soft	Lymphoma cells infiltrate liver sinus, splenic sinusoids	NO	Suspected lymphoid cell

NO, not involved; NE, not evaluable.

Table 3 Immunophenotypic features and TCR rearrangements of hepatosplenic lymphoma.

	CD20	CD79a	CD3	CD4	CD8	CD43	UCHL-1	CD56	TCRγδ	TCR γ gene rearrangement	TCR δ gene rearrangement
1	-	-	+	-	-	+	+	+	-	-	+
2	-	-	+	-	-	+	+	+	NE	+	+
3	-	-	+	NE	-	+	+	+	+	+	-
4	-	-	+	-	+	+	+	+	+	-	-
5	-	-	+	-	+	+	+	+	+	+	+
6	-	-	+	-	+	+	+	+	+	-	+
7	-	-	+	NE	+	+	+	+	+	+	+
8	-	-	+	-	-	+	+	+	-	+	+

+, positive; -, negative; NE, not evaluable.