Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma

Table 1 Fas and FasL expression in tissues of gallbladder carcinoma, adenoma and chronic cholecystitis (mean±SE).

Pathological types	n	Fas+	FasL+	Apoptosis index
Gallbladder carcinoma	26	12	22a	3.88±0.88b
Grading
Well-differentiated	11	7	9	2.73±0.75c
Poorly-differentiated	15	5	13	4.73±1.29
Staging
Nevin I–III	13	5	10	2.62±0.68d
Nevin IV–V	13	7	12	5.15±1.33
Gallbladder adenoma	18	13	15	1.67±0.55
Gallbladder cholecystitis	20	16	11	0.20±0.18

^aP<0.05 (x² = 4.89 vs chronic cholecystitis tissues);

^bP<0.01 (t’ = 4.19 vs gallbladder adenoma tissues; t’ = 8.06 vs chronic cholecystitis tissues);

^cP<0.05 (t’ = 2.63, vs poorly-differentiated gallbladder carcinoma tissues);

^dP<0.01 (t’ = 3.33 vs Nevin IV-V gallbladder carcinoma tissues).

Table 2 Apoptosis quantities and total quantities of infiltrating lymphocytes in tissues of gallbladder carcinoma, adenoma and chronic cholecystitis (mean±SE).

Pathological types	n	Total quantities	Apoptosis quantities
Gallbladder carcinoma	26	20.31±4.46b	3.96±0.84
Grading
Well-differentiated	11	11±2.98d	2.82±1.15i
Poorly-differentiated	15	27.13±5.16	4.8±1.02
Staging
Nevin I–III	13	13.38±4.28f	3.38±1.23
Nevin IV–V	13	27.23±5.81	4.54±1.10
Gallbladder adenoma	18	3.89±1.13	0
Gallbladder cholecystitis	20	1.55±0.54h	0

^bP<0.01 (t’ = 6.99 vs gallbladder adenoma tissues);

^dP<0.01 (t’ = 5.31 vs poorly-differentiated gallbladder carcinoma tissues;

^fP<0.01 (t = 3.76 vs Nevin IV–V gallbladder carcinoma tissues);

^hP<0.01 (t’ = 3.66 vs gallbladder adenoma tissues);

ⁱP<0.05 (t = 2.52 vs poorly-differentiated gallbladder carcinoma tissues).