Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats

Table 1 Effects of recombinant pcDNA3-ALR plasmid on AST, ALT, and PCNA in rats with acute hepatic injury (mean±SD).

Group	n	AST (U/L)	ALT (U/L)	PCNA
Normal control group	6	181.8±14.9	43.3±5.1	6.4±1.3
Model group of hepatic injury	6	3936.2±685.1b	2590.0±350.2b	19.7±2.0b
IV injection (50 µg/kg)	6	2626.2±404.2d	1579.6±330.1d	54.8±5.3d
IV injection (200 µg/kg)	6	921.6±458.2d	572.0±254.2d	66.5±5.3d
IP injection (50 µg/kg)	6	2717.0±1 069. 8d	1589.2±581.6d	40.0±4.9d
IP injection (200 µg/kg)	6	1890.3±610.6d	1495.3±169.3d	45.8±2.6d
Combined injection (200 µg/kg)	6	2135.5±401.1d	1457.8±418.2d	61.1±3.8d

^bP<0.01 vs normal control group,

^dP<0.01 vs model group of hepatic injury.

Table 2 Effect of recombinant pcDNA3-ALR plasmid on survival rate of CCl₄-induced acute hepatic failure in rats in 96 h.

Group	n	Number of survival	Survival rate (%)
Saline	20	3	15
PcDNA3-ALR	20	8	40b

^bP<0.01 vs saline.