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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Jun 28, 2005; 11(24): 3671-3674
Published online Jun 28, 2005. doi: 10.3748/wjg.v11.i24.3671
Published online Jun 28, 2005. doi: 10.3748/wjg.v11.i24.3671
Table 1 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by CCl4 (mean±SD).
Group | Mice (n) | ALT (U/L) | AST (U/L) |
Normal | 10 | 47.68±15.23b | 130.10±74.17b |
Model control | 10 | 511.86±255.86 | 562.93±183.84 |
Positive control | 10 | 269.86±137.86b | 378.42±189.63a |
Picroside II (5 mg/kg) | 10 | 404.15±21.10 | 416.28±230.48 |
Picroside II (10 mg/kg) | 10 | 293.69±177.40a | 402.14±181.09a |
Picroside II (20 mg/kg) | 10 | 242.01±163.96b | 277.46±84.64b |
Table 2 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by AP (mean±SD).
Group | Mice (n) | ALT (U/L) | AST (U/L) |
Normal | 10 | 56.53±11.52b | 151.22±15.87b |
Model control | 10 | 508.91±220.93 | 711.77±151.27 |
Positive control | 10 | 328.67±143.06a | 335.84±257.02b |
Picroside II (5 mg/kg) | 10 | 342.52±186.33 | 411.23±190.89b |
Picroside II (10 mg/kg) | 10 | 225.89±75.28b | 318.17±161.20b |
Picroside II (20 mg/kg) | 10 | 197.87±46.11b | 283.40±140.76b |
Table 3 Effects of picroside II on serum ALT and AST of mice with acute liver injury induced by D-GalN (mean±SD).
Group | Mice (n) | ALT (U/L) | AST (U/L) |
Normal | 10 | 46.59±14.18b | 140.77±11.85b |
Model control | 10 | 1 036.67±588.34 | 800.82±418.75 |
Positive control | 10 | 548.32±254.35a | 502.42±192.43a |
Picroside II (5 mg/kg) | 10 | 635.93±266.90a | 523.56±184.12 |
Picroside II (10 mg/kg) | 10 | 495.3±260.70a | 491.90±116.35a |
Picroside II (20 mg/kg) | 10 | 250.69±142.19b | 368.61±121.79b |
Table 4 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by CCl4 (mean±SD).
Group | M (n) | MDA (nmol/L) | SOD (NU/mL) | GSH-Px (mmol/g) |
Normal | 10 | 4.24±0.46b | 264.82±14.8b | 96.42±8.2b |
Model control | 10 | 8.48±0.56 | 218.41±14.4 | 64.22±5.4 |
Positive control | 10 | 5.46±1.06b | 244.54±12.6a | 80.63±7.2b |
Picroside II (5 mg/kg) | 10 | 6.88±1.12b | 238.63±14.6a | 66.46±6.2 |
Picroside II (10 mg/kg) | 10 | 5.22±0.38b | 250.22±15.2b | 70.82±8.4a |
Picroside II (20 mg/kg) | 10 | 4.46±0.88b | 254.26±16.6b | 88.66±9.8b |
Table 5 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by AP (mean±SD).
Group | M (n) | MDA (nmol/L) | SOD (NU/mL) | GSH-Px (mmol/g) |
Normal | 10 | 1.74±0.32b | 288.61±11.8b | 86.42±4.2b |
Model control | 10 | 5.48±0.24 | 202.42±10.4 | 54.67±3.4 |
Positive control | 10 | 2.46±0.36b | 236.35±14.6b | 70.63±3.2a |
Picroside II (5 mg/kg) | 10 | 2.88±0.42b | 216.62±11.6a | 59.64±2.2 |
Picroside II (10 mg/kg) | 10 | 2.24±0.28b | 250.21±15.2b | 68.82±2.4a |
Picroside II (20 mg/kg) | 10 | 2.02±0.12b | 278.23±14.2b | 81.62±6.8b |
Table 6 Effects of picroside II on MDA, SOD, and GSH-Px of mice with acute liver damage induced by D-GalN (mean±SD).
Group | M (n) | MDA (nmol/L) | SOD (NU/mL) | GSH-Px (mmol/g) |
Normal | 10 | 2.24±0.22b | 302.28±16.8b | 82.24±3.22b |
Model control | 10 | 6.64±0.32 | 246.62±15.2 | 58.32±2.22 |
Positive control | 10 | 3.48±0.16b | 284.25±12.2b | 72.28±3.01a |
Picroside II (5 mg/kg) | 10 | 4.88±0.42a | 254.64±14.4 | 61.24±2.64 |
Picroside II (10 mg/kg) | 10 | 3.22±0.26b | 268.28±14.2a | 70.26±2.86a |
Picroside II (20 mg/kg) | 10 | 3.02±0.24b | 286.24±16.2b | 78.24±3.12b |
Table 7 Effects of picroside II on activities of ATPase and swelling extent of mitochondria of mice with acute liver damage induced by AP (mean±SD).
Group | Mice (n) | Activities of ATPase mmol (pi)/(h·mg) (protein) | Swelling extent of mitochondria 0-5 min A520 | Swelling extent of mitochondria 5-10 min A520 |
Normal | 10 | 24.24±0.26a | 0.528±0.004b | 0.520±0.002b |
Model control | 10 | 20.18±0.16 | 0.462±0.002 | 0.432±0.001 |
Positive control | 10 | 23.48±0.16a | 0.495±0.001b | 0.476±0.001a |
Picroside II (5 mg/kg) | 10 | 21.01±0.42 | 0.474±0.002 | 0.450±0.002b |
Picroside II (10 mg/kg) | 10 | 23.22±0.26a | 0.496±0.001a | 0.484±0.002a |
Picroside II (20 mg/kg) | 10 | 25.02±0.24a | 0.512±0.006b | 0.502±0.004b |
- Citation: Gao H, Zhou YW. Anti-lipid peroxidation and protection of liver mitochondria against injuries by picroside II. World J Gastroenterol 2005; 11(24): 3671-3674
- URL: https://www.wjgnet.com/1007-9327/full/v11/i24/3671.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i24.3671