Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China

Table 1 Demographic characteristics of GCA patients and healthy individuals.

Groups	Control n (%)	GCA n (%)	P
Sex
Male	201 (68.4)	159 (75.0)	0.10
Female	93 (31.6)	53 (25.0)
Mean age in years (SD)	59.1 (10.2)	60.4 (8.4)	0.09
Smoking status
Ex- or current smoker	103 (43.3)	114 (58.2)	0.0025
Non-smoker	135 (56.7)	82 (41.8)
Family history of UGIC
Positive	9 (5.5)	57 (30.6)	<0.0001
Negative	156 (94.5)	129 (69.4)

Table 2 Influence of DNMT3B SNP on the risk of development and lymphatic metastases of GCA.

Group	DNMT3B genotype T/T	n (%) C/T	aOR (95%CI)	P
Overall
Control	279 (94.9)	15 (5.1)
GCA	205 (96.7)	7 (3.3)	0.66 (0.26-1.67)	0.38
Nonsmoker
Control	130 (96.3)	5 (3.7)
GCA	78 (95.1)	4 (4.9)	1.43 (0.37-5.56)	0.61
Smoker
Control	98 (95.1)	5 (4.9)
GCA	111 (97.4)	3 (2.6)	0.61 (0.14-2.69)	0.51
Family history of UGIC in
GCA patients	82 (96.5)	3 (3.5)	0.40(0.05-3.14)	0.38
Positive	97 (96.0)	4 (4.0)	0.94 (0.35-2.50)	0.91
Negative
GCA with LM data
LM- (n = 62)	58 (93.5)	4 (6.5)
LM+(n = 69)	67 (97.1)	2 (2.9)	0.45 (0.08-2.63)	0.38

LM: lymphatic metastasis.