Correlative studies on bFGF mRNA and MMP-9 mRNA expressions with microvascular density, progression, and prognosis of gastric carcinomas

Table 1 Correlation of bFGF and MMP-9 mRNA expression and pathological parameters in 105 gastric carcinoma cases.

Groups	n	bFGFmRNA				rs	P	MMP-9mRNA				rs	P
		-	+	++	+++			-	+	++	+++
Growth pattern						0.324	0.001					0.267	0.006
Expansive	48	27	8	8	5			27	12	9	0
Infiltrative	57	14	7	20	16			17	13	21	6
Invasive depth						0.211	0.031					0.335	0.001
T1-T2	44	31	5	5	3			26	11	6	1
T3-T4	61	10	10	23	18			18	14	24	5
Vessel invasion						0.579	0.001					0.209	0.032
Absent	29	25	2	2	0			17	7	4	1
Present	76	16	13	26	21			27	18	26	5
Lymph node metastasis						0.405	0.001					0.343	0.001
Absent	35	25	4	4	2			21	6	7	1
Present	70	16	11	24	19			23	19	23	5
Distant metastasis						0.474	0.001					0.468	0.001
Absent	63	37	14	8	4			40	9	10	4
Present	42	4	1	20	17			4	16	20	2

Table 2 MVD in different gastric carcinoma pathological parameters (number/0.72 mm², mean±SD).

Groups	n	MVD	t	P
Tumor differentiation			0.965	0.337
High-moderate	63	38.33±14.83
Low-undifferentiated	42	41.09±13.97
Growth pattern			10.105	0.001
Expansive	48	34.70±15.23
Infiltrative	57	43.42±12.64
Invasive depth			5.961	0.001
T1-T2	44	30.84±13.66
T3-T4	61	45.64±11.69
Vessel invasion			7.394	0.001
Absent	29	25.69±10.11
Present	76	44.68±12.33
Lymph node metastasis			3.819	0.01
Absent	35	27.07±11.33
Present	70	45.62±11.69
Distant metastasis			10.578	0.001
Absent	63	31.30±12.97
Present	42	52.19±6.42

Table 3 Correlation of MVD with bFGFmRNA , MMP-9mRNA expression in 105 cases of gastric cancer.

Groups	n	MVD (number/0.72 mm2)	t	P
bFGFmRNA			3.207	0.002
+-+++	64	46.09±11.52
-	41	29.41±12.47
MMP-mRNA			7.305	0.001
+-+++	61	43.75±13.41
-	44	33.45±13.92

Table 4 Correlation of MVD, bFGF, and MMP-9mRNA expression with survival rate.

Groups	n	Mean survival time (mo)	Five-year survival rate (%)	P
MVD				0.035
<39.5	67	70.42±5.82	63.30 (42/67)
≥39.5	38	18.57±3.76	16.95 (6/38)
bFGFmRNA				0.001
-	41	118.0±46.52	87.06 (38/41)
+-+++	64	33.06±3.57	16.21 (10/64)
MMP-mRNA				0.002
-	44	107.2±87.20	81.82 (36/44)
+-+++	61	42.42±8.25	16.02 (9/61)