Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer

doi:10.3748/wjg.v11.i18.2744

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May 14, 2005 (publication date) through Dec 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2005; 11(18): 2744-2747
Published online May 14, 2005. doi: 10.3748/wjg.v11.i18.2744

Table 1 pBcl-2 and pBax expression and their relationship with clinicopathological parameters for the patients with pancreatic cancer.

Parameter		No. of patients	Number of pBcl-2 and pBax expressing (%)
Parameter		No. of patients	pBcl-2 (+)	pBcl-2 (-)	PBax (+)	PBax (-)
Overall		59	21 (35.6)	38 (64.4)	29 (49.2)	30 (50.8)
Age (yr)	<65	47	17 (36.2)	30 (63.8)	26 (55.3)	21 (44.7)
	≥65	12	4 (33.3)	8 (66.7)	3 (25)	9 (75)
Gender	Male	38	14 (36.8)	24 (63.2)	18 (47.3)	20 (52.7)
	Female	21	7 (33.3)	14 (66.7)	11 (52.4)	10 (47.6)
TNM stage	I	4	1 (25)	3 (75)	3 (75)	1 (25)
	II	8	5 (62.5)	3 (37.5)	4 (50)	4 (50)
	III	42	14 (33.3)	28 (66.7)	19 (45.2)	23 (54.8)
	IV	5	1 (20)	4 (80)	3 (60)	2 (40)
Grade	Well	19	8 (42.1)	11 (57.9)	11 (57.9)	8 (42.1)
	Moderate	21	8 (38.1)	13 (61.9)	8 (38.1)	13 (61.9)
	Poor	19	5 (26.3)	14 (73.7)	10 (52.6)	9 (47.7)

Table 2 Correlation between various factors and survival time by Cox proportional hazards model (dependent variable, mo; censoring variable, death due to pancreatic cancer).

Variable	Parameter estimate (SE)	Conditional risk ratio (95% CI)	P (χ²)
Overall pBcl-2	-1.216 (0.340)	0.297 (0.152-0.577)	0.001
(n = 59) TNM	0.582 (0.246)	1.790 (1.104-2.902)	0.018
Age (yr)	0.037 (0.017)	1.038 (1.004-1.073)	0.026
pBax	0.734 (0.360)	2.084 (1.029-4.222)	0.041
Site	-0.566 (0.487)	0.568 (0.219-1.474)	0.245
Grade	0.169 (0.268)	1.184 (0.701-2.001)	0.528
Gender	0.061 (0.352)	1.063 (0.534-2.118)	0.862

Citation: Dong M, Zhou JP, Zhang H, Guo KJ, Tian YL, Dong YT. Clinicopathological significance of Bcl-2 and Bax protein expression in human pancreatic cancer. World J Gastroenterol 2005; 11(18): 2744-2747
URL: https://www.wjgnet.com/1007-9327/full/v11/i18/2744.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i18.2744