Dynamic expression of pepsinogen C in gastric cancer, precancerous lesions and Helicobacter pylori associated gastric diseases

Table 1 Expression of PGC antigen in various gastric lesions.

Gastric lesions	n	Number of cases with PGC expression				Positive rate (%)	Over-expressionrate (%)
		-	+	++	+++
Normal gastric mucosa	54	0	1	14	39	100.0b	98.2b
Superficial gastritis	58	0	15	26	17	100.0b	74.1bdf
Gastric ulcer or erosion	37	4	20	13	0	89.2abc	35.1bcd
Atrophic gastritis	91	79	11	1	0	14.3bdf	1.1df
Intestinal metaplasia	91	91	0	0	0	0.0dfh	0.0af
Dysplasia	66	56	9	1	0	15.2bdf	1.5df
Gastric cancer	124	121	3	0	0	2.4df	0.0df

^bP<0.01 vs gastric cancer;

^dP<0.01,

^aP<0.05 vs normal gastric mucosa;

^cP<0.05 vs superficial gastritis;

^fP<0.01 vs gastric ulcer or erosion;

^hP<0.01 vs dysplasia.

Table 2 Expression of PGC antigen in different histopathologic types of gastric cancer.

Histopathologic type of gastric cancer	n	No. of cases with PGC expression	Positive rate (%)
Well-differentiated	32	3	9.4
Moderately-differentiated	31	0	0.0
Poorly-differentiated	61	0	0.0a

^aP<0.05 χ² = 0.015 0/61 vs 3/32.

Table 3 Expression of PGC in H pylori-associated gastric lesions.

astric lesions	n	H pylori positive				n	H pylori negative
		PGC positive expression		PGC over-expression			PGC positive expression		PGC over-expression
		n	Rate (%)	n	Rate (%)	n	Rate (%)	n	Rate (%)
Superficial gastritis	33	33	100.0	28	84.8	25	25	100.0	15	60.0a
Atrophic gastritis	61	4	6.6	0	0.0	30	9	30.0b	1	3.3
Intestinalmetaplasia	61	0	0.0	0	0.0	30	0	0.0	0	0
Dysplasia	40	4	10.0	0	2.5	19	6	31.6	0	0.0
Gastric cancer	58	0	0.0	0	0.0	52	3	5.8	0	0

^aP<0.05, χ² = 0.032; 28/33 vs 15/25;

^bP<0.01, χ² = 0.003; 4/61 vs 9/30.