Correlation between CD4, CD8 cell infiltration in gastric mucosa, Helicobacter pylori infection and symptoms in patients with chronic gastritis

Table 1 Changes CD4 and CD8 cells in H pylori positive and negative cases (mean±SD).

HP infection	n	CD4	CD8
Positive	45	9102.82±2747.18a	6285.67±3308.74
Negative	17	6255.33±3284.88	6992.91±3524.89

^aP<0.05 vs negative cases.

Table 2 Correlation between symptoms and CD4 cell infiltrations.

P	Symptom
P = 0.01-0.05	Heavy head or heavy body (t = 2.563), thirst (t = 2.478)
P = 0.06-0.2	Lower spirit, weakness of body or faint limbs, irritation
P = 0.21-0.5	Stomachache, hard stool, weak taste without thirst, distending fullness in chest, cool limbs with aversion to cold
P>0.6	Distending fullness in abdomen, diarrhea, constipation, acid regurgitation and epigastric upset, nausea or vomiting

Table 3 Correlation between symptoms and CD8 cell infiltrations.

P	Symptom
P = 0.01-0.05	Cool limbs with aversion to cold (t = 2.872)
P = 0.06-0.2	Stomachache, nausea or vomiting
P = 0.21-0.5	Weakness of body or faint limbs
P>0.6	Heavy feeling of head or body, thirst, distending fullness in abdomen, diarrhea, constipation, acid regurgitation and epigastric upset, hard stool, weak taste without thirst, distending fullness in chest, lower spirit, irritation

Table 4 Effect of symptom assemblages on the predicted percentage of CD4 and CD8 cell infiltrations.

Symptom	Cell level	Predicted percentage of CD4	Predicted percentage of CD8
Digestion related	Lower	62.5	89.2
	Higher	62.1	16.7
	Overall	62.3	60.7
Non-digestion related	Lower	75.0	83.8
	Higher	58.6	50.0
	Overall	67.2	70.5

Table 5 Effect of symptom assemblages on the predicted percentage of H pylori infection.

Symptom	H pylori infection	Predicted percentage
Digestion related	Negative	17.6
	Positive	95.5
	Overall	73.8
Non-digestion related	Negative	41.2
	Positive	93.2
	Overall	78.7

Table 6 Effect of symptom assemblage based on K-mean cluster analysis on the predicted percentage of CD4 and CD8 infiltrations and H pylori infection.

Symptom	Infiltration	Predicted percentage of CD4	Predicted percentage of CD8	H pylori infection	Predicted percentage
Category one1	Lower	78.1	100	Negative	0
	Higher	44.8	0	Positive	100
	Overall	62.3	60.7	Overall	72.1
Category two1	Lower	68.8	81.1	Negative	35.3
	Higher	62.1	58.3	Positive	90.9
	Overall	65.6	72.1	Overall	75.4

¹Category one included distending fullness in abdomen, stomachache, diarrhea, regurgitation and epigastric upset, and category two had other symptoms.

Table 7 Difference of symptoms between the two clusters of cases based on the symptoms, CD4 and CD8 cell infiltrations.

P	Symptom
P = 0.01-0.05	Weakness of body or faint limbs (F = 5.005), lower spirit (F = 5.750), hard stool (F = 5.835)
P = 0.06-0.2	Constipation, thirst, distending fullness in chest, nausea or vomiting
P = 0.21-0.5	Stomachache, diarrhea, weak taste without thirst, cool limbs with aversion to cold
P>0.6	Heavy feeling of head or body, distending fullness in abdomen, acid regurgitation and epigastric upset, irritation