Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Apr 21, 2005; 11(15): 2238-2243
Published online Apr 21, 2005. doi: 10.3748/wjg.v11.i15.2238
Published online Apr 21, 2005. doi: 10.3748/wjg.v11.i15.2238
Table 1 Demographic and clinical data of 332 patients with chronic HBV infection.
Diagnosis | n | Sex (m/f) | Age (yr) | ALT (U/L) | HBeAg positive | Genotype | |||
A | B | C | U | ||||||
Carrier | 93 | 57/36 | 30.9±10.6 | 27.5±4.5 | 42/82 (51.2) | 2 (2.2) | 16 (17.2) | 73 (78.4) | 2 (2.2) |
CH | 103 | 84/19 | 36.2±10.1 | 157.4±103.8 | 61/92 (66.3) | 5 (4.9) | 20 (19.4) | 76 (73.8) | 2 (1.9) |
Cirrhosis | 60 | 47/13 | 48.8±13.8 | 135.0±90.9 | 26/53 (49.1) | 2 (3.3) | 10 (16.7) | 44 (73.3) | 4 (6.7) |
HCC | 76 | 60/16 | 54.4±12.9 | 107.8±107.4 | 15/71 (21.1) | 2 (2.6) | 23 (30.3) | 50 (65.8) | 1 (1.3) |
Table 2 Demographic and clinical data of patients with chronic hepatitis.
Characteristics | Genotype B (n = 20) | Genotype C (n = 76) | P |
Age (yr) | 35.1±9.6 | 36.4±10.3 | NS |
Sex (male/female) | 16/4 | 65/11 | NS |
Total bilirubin (mg/dL) | 0.8±0.2 | 0.7±0.3 | NS |
ALT (IU/L) | 119.8±58.5 | 159.8±106.4 | 0.03 |
HBeAg positive | 8/18 (44.4) | 53/74 (71.6) | 0.03 |
HBV DNA (LGE/mL) | 7.25±1.74 | 7.10±1.34 | NS |
HAI inflammation | 5.8±2.1 | 6.7±2.1 | NS |
HAI fibrosis | 1.5±1.0 | 1.8±0.9 | NS |
Table 3 Demographic and clinical data of patients with cirrhosis.
Characteristics | Genotype B (n = 10) | Genotype C (n = 44) | P |
Age (yr) | 54.7±9.2 | 47.4±14.4 | 0.06 |
Sex (male/female) | 8/2 | 35/9 | NS |
Total bilirubin (mg/dL) | 1.4±0.8 | 2.2±1.2 | NS |
ALT (IU/L) | 101.5±49.0 | 133.7±93.4 | NS |
Albumin (g/dL) | 3.7±0.4 | 3.8±0.5 | NS |
HBeAg positive | 1/9 (11.1) | 25/44 (56.8) | 0.01 |
HBV DNA (LGE/mL) | 6.59±1.20 | 7.05±2.50 | NS |
Child classification (A/B/C) | 7/2/1 | 24/15/5 | NS |
Table 4 Demographic and clinical data of patients with HCC.
Characteristics | Genotype B (n = 23) | Genotype C (n = 50) | P |
Age (yr) | 61.1±9.8 | 51.3±13.1 | 0.001 |
Sex (male/female) | 20/3 | 38/12 | NS |
Total bilirubin (mg/dL) | 2.1±2.0 | 2.9±4.9 | NS |
ALT (IU/L) | 95.5±102.6 | 121.4±126.1 | NS |
Albumin (g/dL) | 3.4±0.7 | 3.5±0.5 | NS |
HBeAg positive | 4/22 (18.1) | 11/49 (22.4) | NS |
HBV DNA (LGE/mL) | 6.71±1.62 | 6.52±2.63 | NS |
AFP (IU/mL) | 42 485.2±95 590.9 | 42 032.6±89 382.8 | NS |
CLIP score (0-1/2-3/4-6) | 5/7/11 | 8/25/17 | NS |
Table 5 Multivariate analysis of unfavorable factors of survival in patients with HCC, by using Cox regression analysis.
Factors | Risk ratio | 95%CI | P |
CLIP stage | 4.63 | 1.70-12.62 | 0.003 |
No therapy | 6.22 | 2.54-15.22 | 0.001 |
- Citation: Tangkijvanich P, Mahachai V, Komolmit P, Fongsarun J, Theamboonlers A, Poovorawan Y. Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand. World J Gastroenterol 2005; 11(15): 2238-2243
- URL: https://www.wjgnet.com/1007-9327/full/v11/i15/2238.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i15.2238