Etiological role of brucellosis in autoimmune hepatitis

Table 1 AIH scoring system.

Category	Feature	Score	Patient
Gender	Female	+2	+2
ALP:AST (or ALT) ratio	<1.5	+2	-2
	1.5-3.0	0
	>3.0	-2
Gamma globulin or Ig G levels over	>2.0	+3	+3
normal values	1.5-2.0	+2
	1.0-1.5	+1
	<1.0	0
ANA, SMA, or anti-LKM1 titer	>1:80	+3	+3
	1:80	+2
	1:40	+1
	<1:40	0
AMA	Positive	-4	-4
Viral markers	Positive	-3	+3
	Negative	+3
Drugs	Yes	-4	-4
	No	+1
Alcohol	<25 g/d	+2	+2
	>60 g/d	-2
HLA	DR3 or DR4	+1
Immune disease	Thyroiditis, colitis, synovitis, others	+2	0
Other liver-related antibodies	Anti-SLA/LP, anti-aktin, anti-LC1, p-ANCA	+2	0
Histologic features	Interface hepatitis	+3	+3
	Plasmocytes	+1	+1
	Rosette formation	+1	0
	None of the above	-5	0
	Biliary changes	-3	-3
	Other features	-3	0
Response to therapy	Complete	+2	2
	Relapse	+3
Score before therapy
Absolute diagnosis		>15	6
Probable diagnosis		10-15

Abbreviations: ALP, serum alkaline phosphatase level; AST, serum aspartate aminotransferase level; ALT, serum alanine aminotransferase level; ANA, anti-nuclear antibody; SMA, smooth muscle antikoru; anti-LKM1, antibody against liver/kidney type 1; AMA, anti-mitochondrial antibody; anti-SLA/LP, antibody against soluble liver antigen/liver pancreas; anti-LC1, antibody against liver cytosole type 1; p-ANCA, perinuclear anti-neutrophilic cytoplasmic antibody.