Risk factors for the recurrence of hepatocellular carcinoma after radiofrequency ablation of hepatocellular carcinoma in patients with hepatitis C

Table 1 Patient’s characteristics.

Gender	1
Number of males	19(73%)
Number of females	7(27%)
Median age	67.9
Child-Pugh A	15(58%)
B	11(42%)
C	0(0%)
Number of HCC nodules
Uninodular	13(50%)
Multinodular	13(50%)
Mean follow-up period (months)
With recurrence	12.5
Without recurrence	20

Table 2 Comparison of patients with and without recurrence of primary HCC in the liver.

Variable	With recurrence(n = 12)	Without recurrence(n = 14)	P
Age (yr)	67.8 ± 5.7	67.9 ± 7.8	NS
Gender
Male	6	11	NS
Female	6	3
Nodule diameter (mm)	23.5 ± 7.2	32.0 ± 24.2	NS
Number of primary
HCC nodules
Uninodular	3	10	<0.05
Multinodular	9	4
Child-Pugh A	6	9	NS
B	6	5
Platelet (/mL)	8.2 ± 3.6	13.3 ± 6.9	<0.05
Albumin (g/L)	3.2 ± 0.3	3.4 ± 0.4	NS
AST (IU/L)	197.7 ± 416.0	87.2 ± 47.2	NS
Post-RFA AST (IU/L)	72.4 ± 25.4	70.8 ± 2.96	NS
ALT (IU/L)	98.0± 121.6	76 ± 43.5	NS
Post-RFA ALT (IU/L)	49.3 ±21.4	55.4 ± 30.5	NS
Post-RFA treatment
UDCA	10	12	NS
SNMC	5	4
IFN	0	2

Table 3 Multivariate analysis for prognostic factors of recurrence.

Variables CI	Ungav. /fav.1	Relative risk	CI	P
Multinodular	Multinodular/ Uninodular	6.970	1.443-33.667	0.016
Post-RFA AST2	>40/< = 40 (IU/L)	2.438	0.213-27.956	0.474
Platelet2	10>/> = 10 (/mL)	2.426	0.445-13.222	0.306
Nodule diameter2	30>/> = 30 (mm)	1.032	0.217-4.903	0.969
Child-Pugh	B/A	0.861	0.184-4.025	0.849
Gender	Males/female	0.627	0.132-2.986	0.558
Age (yr)2	68>/< = 68 (yr)	0.406	0.076-2.169	0.292

¹Unfav./fav., unfavorable vs favorable CI, 95%;

²Mean.