Plasma von Willebrand factor level as a prognostic indicator of patients with metastatic colorectal carcinoma

Table 1 Patients’ characteristics according to different plasma vWF levels.

Characteristics	vWF ≤160%	vWF ≤160%	P
n	53	33
Age (yr)			0.986
<50	23	14
50-70	18	11
>70	12	8
Gender			0.496
Male	36	20
Female	17	13
Performance status			0.656
0	32	18
1. 2	21	15
Primary tumor			0.825
Colon	28	16
Rectum	25	17
Extent of metastases			0.014
One site	20	22
Multiple sites	33	11
Site of metastases			0.11
Liver	37	17
Lung	34	20
Lymph nodes	6	3
Peritoneum	8	5
Others	3	1
Histology			0.558
Well-differentiated	8	5
Moderately-differentiated	25	19
Poorly-differentiated	13	4
Unknown	7	5
Serum CEA level			0.646
≤20 ng/mL	19	10
≤20 ng/mL	34	23

CEA: Carcinoembryonic antigen; vWF: Von Willebrand factor.

Table 2 Analysis of prognostic factors on survival.

Variables	n	Univariate(P)	Multivariate(P)
Age (yr)
<50	37	0.528	-
≥50	49
Gender
Male	56	0.986	-
Female	30
Performance status
0	50	0.022	0.014
1. 2	36
Site of primary
tumor
Colon	44	0.430	-
Rectum	42
Extent of metastases
One site	42	0.028	0.012
Multiple sites	44
Liver metastases
Present	54	0.658	-
Absent	32
Lung metastases
Present	54	0.443	-
Absent	32
Histological
differentiation
Well/moderate	57	0.718	-
Poor/unknown	29
Pre-treatment CEA
≤6 ng/mL	29	0.213	-
>6 ng/mL	57
Pre-treatment vWF
≤160%	33	<0.001	<0.001
>160%	53

CEA, carcinoembryonic antigen; vWF: von Willebrand factor; -: no significance.