Clinical significance of hepatic derangement in severe acute respiratory syndrome

Table 1 Univariate analysis of baseline clinical characteristics among patients with peak ALT levels > 5×ULN vs with patients with peak ALT levels ≤ 5×ULN.

	Peak ALT >5×ULN	Peak ALT ≤5×ULN	P
Number of patients	28	265
Age (yr)	40±14	39±15	0.68
Male	17 (61%)	109 (41%)	<0.001
Co-morbid	4 (14%)	37 (14%)	0.002
Hemoglobin (g/dL)	13.4±2.1	13.4± 1.5	0.94
White cell count (×109/L)	5.3±2.3	5.0±2.0	0.49
Neutrophil (×109/L)	4.2±1.9	3.8±1.9	0.30
Lymphocyte (×109/L)	0.8±0.5	0.8±0.5	0.90
Platelet (×109/L)	146±53	151±53	0.64
Creatinine (mmol/L)	83 (481-318)	79 (43-214)	0.09
HBsAg	6/25 (24%)	24/218 (11%)	<0.001
Oxygen supplementation	21 (75%)	120 (45%)	<0.001
ICU care	11 (39%)	39 (15%)	<0.001
Mechanical ventilation	9 (32%)	24 (9%)	0.012
Death	7 (25%)	20 (8%)	0.017

Table 2 Clinical outcome of patients with and without chronic hepatitis B.

	HBsAg positive	HBsAg negative	P
Number of patients	30	214
Peak ALT (×ULN)	2.2 (0.6-26.1)	1.5 (0.3-316.3)	0.16
Oxygen supplementation	17 (57%)	104 (49%)	0.68
ICU care	5 (17%)	30 (14%)	0.70
Mechanical ventilation	3 (10%)	19 (9%)	0.84
Death	2 (7%)	14 (7%)	0.98