Ou DP, Yang LY, Huang GW, Tao YM, Ding X, Chang ZG. Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV. World J Gastroenterol 2005; 11(14): 2061-2066 [PMID: 15810069 DOI: 10.3748/wjg.v11.i14.2061]
Corresponding Author of This Article
Professor. Lian-Yue Yang, Liver Cancer Laboratory, Department of Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. lianyueyang@hotmail.com
Article-Type of This Article
Liver Cancer
Open-Access Policy of This Article
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Type of liver resection (non-anatomical/anatomical)
149/121
78/58
59/48
19/10
Incisal margin ( ≤1 cm/>1 cm)
22/258
15/131
14/93
1/28
HBV infection (positive/negative)
239/31
128/8
102/5
26/3
Blood transfusion (yes/no)
199/71
100/36
75/32
25/4
Survival time (d)
–
575.9±499.6
384.7±313.1
1248.5±450.9
Recurrent time (d)
–
435.6±417.9
23.1±199.6
1072.2±396.9
Table 2 Multiple regression analysis of recurrence and metastasis of 136 HCC patients.
Variable
Results on early phase
Results on late phase
Regression coefficient
t
P
Regression coefficient
t
P
AFP level
-0.328
-3.693
0.000
-0.280
-1.306
0.208
Hepatocirrhosis
0.024
0.274
0.785
-0.377
-1.530
0.143
Type of liver resection
0.023
0.260
0.795
0.245
1.235
0.233
Incisal margin
0.217
2.485
0.015
0.106
0.420
0.679
Blood transfusion
-0.223
2.553
0.012
0.268
1.266
0.222
Gross tumor classification
-0.051
-0.583
0.561
-0.518
-2.433
0.026
Vascular invasion
0.266
3.013
0.003
-0.361
-1.562
0.136
Tumor capsule
0.023
0.259
0.797
-0.281
-1.111
0.281
Edmondson classification
0.126
1.444
0.152
0.065
0.292
0.774
Table 3 Statistics of the HBV infective pattern.
Serum markers
All patients (n = 270)
Recurrent patients (n = 136)
Positive number
Ratio (%)
Positive number
Ratio (%)
HBsAg+HBeAg+HBcAb+
20
7.4
14
10.3
HBsAg+HBeAb+HBcAb+
118
43.7
62
45.6
HBsAg+HBcAb+
57
21.1
32
23.5
HBsAb+
9
3.3
6
4.4
HBcAb+
2
0.7
2
1.5
HBeAb+HBcAb+
7
2.6
1
0.7
HBsAg+
16
5.9
9
6.6
HBsAb+HBeAb+HBcAb+
2
0.7
0
0.0
HBsAg+HBeAb+
6
2.2
1
0.7
HBsAb+HBeAb+
2
0.7
1
0.7
HBV negative
31
11.5
8
5.9
Table 4 Compare the HBV infective pattern between SLHCC and NHCC.
Serum markers
All patients (n = 270)
Recurrent patients (n = 136)
χ2
P
SLHCC ratio (%)
NHCC ratio (%)
SLHCC ratio (%)
NHCC ratio (%)
HBsAg+HBeAg+HBcAb+
40.0
13.3
33.3
25.0
4.244
0.039
HBsAg+HBeAb+HBcAb+
56.3
12.5
53.1
12.2
0.003
0.955
HBsAg+HBcAb+
70.2
12.8
73.1
11.5
0.079
0.778
HBsAb+
71.4
14.3
60.0
20.0
1.833
0.176
HBeAb+HBcAb+
75.0
12.5
0.0
100.0
4.876
0.000
HBsAg+
63.2
5.3
50.0
12.5
4.867
0.027
HBV negative
69.6
4.3
87.5
0.0
4.877
0.027
Citation: Ou DP, Yang LY, Huang GW, Tao YM, Ding X, Chang ZG. Clinical analysis of the risk factors for recurrence of HCC and its relationship with HBV. World J Gastroenterol 2005; 11(14): 2061-2066