Copyright
©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Mar 28, 2005; 11(12): 1867-1871
Published online Mar 28, 2005. doi: 10.3748/wjg.v11.i12.1867
Published online Mar 28, 2005. doi: 10.3748/wjg.v11.i12.1867
Table 1 Select characteristics of cardia cancer cases (n = 159) and controls (n = 192).
Variable | Cases | Controls | P | ||
n | (%) | n | (%) | ||
Age (yr) | |||||
≤59 | 62 | 39.0 | 93 | 48.4 | |
60-69 | 61 | 38.4 | 60 | 31.3 | |
≥70 | 36 | 22.6 | 39 | 20.3 | 0.196 |
Sex | |||||
Female | 30 | 18.9 | 52 | 27.1 | |
Male | 129 | 81.1 | 140 | 72.9 | 0.07 |
Education (yr) | |||||
<12 | 95 | 59.7 | 89 | 46.4 | |
≥12 | 64 | 40.3 | 103 | 53.6 | 0.012 |
Table 2 Association of CYP2E1 polymorphisms with cardia cancer risk.
CYP2E1 | Cases | Controls | OR (95%CI)1 | ||
N | % | N | % | ||
C1/c2 | 57 | 35.8 | 110 | 57.3 | 1 |
C2/c2 | 6 | 3.8 | 5 | 2.6 | |
C1/c1 | 96 | 60.4 | 77 | 40.1 | 2.37 (1.52-3.70) |
Table 3 Associations of cardia cancer risk with joint distribution of CYP2E1 genotypes and smoking status.
Smoking status | CYP2E1 | Cases | Controls | OR (95%CI)1 | OR (95%CI)2 | ||
n | % | n | % | ||||
Smoking | |||||||
Never | c1/c2 or c2/c2 | 33 | 20.75 | 55 | 28.65 | 1 | 1 |
Ever | C1/c1 | 35 | 22.01 | 53 | 27.60 | 1.05 (0.561.99) | 1.03 (0.522.06) |
Ever | c1/c2 or c2/c2 | 30 | 18.87 | 60 | 31.25 | 0.85 (0.401.78) | 0.91 (0.392.14) |
Ever | C1/c1 | 61 | 38.36 | 24 | 12.50 | 4.68 (2.1910.04) | 3.94 (1.609.67) |
Daily consumed cigarettes | |||||||
1-19 | c1/c2 or c2/c2 | 8 | 5.03 | 15 | 7.81 | 0.81 (0.272.39) | 0.62 (0.182.16) |
1-19 | C1/c1 | 9 | 5.66 | 6 | 3.13 | 2.99 (0.8810.19) | 2.59 (0.5412.45) |
≥20 | c1/c2 or c2/c2 | 22 | 13.84 | 45 | 23.44 | 0.90 (0.411.98) | 1.04 (0.412.67) |
≥20 | C1/c1 | 52 | 32.70 | 18 | 9.38 | 5.34 (2.3811.95) | 4.17 (1.6310.63) |
Smoking duration (yr) | |||||||
1-29 | c1/c2 or c2/c2 | 10 | 6.29 | 25 | 13.02 | 0.71 (0.271.87) | 0.82 (0.272.49) |
1-29 | C1/c1 | 19 | 11.95 | 18 | 9.38 | 2.10 (0.855.21) | 1.99 (0.616.49) |
≥30 | c1/c2 or c2/c2 | 20 | 12.58 | 35 | 18.23 | 1.10 (0.472.57) | 1.00 (0.372.69) |
≥30 | C1/c1 | 42 | 26.42 | 6 | 3.13 | 13.32 (4.5039.45) | 8.44 (2.5827.59) |
- Citation: Cai L, Zheng ZL, Zhang ZF. Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer. World J Gastroenterol 2005; 11(12): 1867-1871
- URL: https://www.wjgnet.com/1007-9327/full/v11/i12/1867.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i12.1867