Apoptosis of human gastric cancer SGC-7901 cells induced by mitomycin combined with sulindac

Table 1 Effect of drugs on apoptosis and cell cycle of SGC-7901 cell line (%, mean±SD).

Group	Apoptosis	G0 /G1	S	G2/M
Control	0.43±0.38	47.43±2.81	45.50±1.25	7.06±4.06
Sulindac	3.80±0.53a	49.67±3.29	44.70±5.82	4.97±6.52
MMC	7.20±1.31a	56.67±3.92a	40.40±11.53	6.60±2.99
Combined	11.9±2.59b	68.40±5.53b	29.23±5.87	2.37±0.45

^aP<0.05 vs control,

^bP<0.01 vs MMC.

Table 2 Expression of COX-2, Bcl-2 protein in SGC-7901 cells after incubated with three drugs for 24 h (mean±SD, n = 3, A).

Group	COX-2	Bcl-2
Control	0.4980±0.0330	0.3652±0.057
Sulindac	0.3967±0.0306a	0.2617±0.0333b
MMC	0.5633±0.0208	0.4500±0.0436b
Combined	0.4000±0.0265ac	0.3660±0.0397c

^aP<0.05,

^bP<0.01, vs control,

^cP<0.05 vs MMC.