Clinicopathological and molecular genetic analysis of HNPCC in China

Table 1 MSI status, immunostaining of nine tumors in five HNPCC kindreds.

Family	Criteria	Tumor	BAT26	D2S123	BAT25	D3S346	D17S250	MSIstatus	Determination	hMSH2 protein	hMLH1 protein
H1	AC	CRC	+	+	+	+	+	5/5	MSI-H	Negative	N
H2	AC	CRC	+	+	+	+	+	5/5	MSI-H	N	Negative
H5-1	AC	CRC	+	+	+	+	+	5/5	MSI-H	N	N
H5-2	AC	CRC	+	-	+	+	+	4/5	MSI-H	N	N
H5-3	AC	CRC	+	NR	+	NR	NR	2/2	MSI-H	N	N
H6	JC	CRC	+	+	+	-	-	3/5	MSI-H	N	N
H7-1	AC	CRC	+	+	+	+	+	5/5	MSI-H	Negative	N
H7-2	AC	CRC	+	NR	+	+	+	4/4	MSI-H	Negative	N
H7-3	AC	CRC	-	+	+	-	+	3/5	MSI-H	Negative	N

AC: Amsterdam criteria; JC: Japanese criteria; NR: no result; MSI-H: high-level microsatellite instability; N: normal expression protein.