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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Mar 21, 2005; 11(11): 1616-1622
Published online Mar 21, 2005. doi: 10.3748/wjg.v11.i11.1616
Published online Mar 21, 2005. doi: 10.3748/wjg.v11.i11.1616
Table 1 Gender- and age-specific prevalence of elevated serum alanine aminotransferase (ALT) level among subjects aged 30 and above in Kinmen.
| Age (yr) | Level of ALT (U/L) | |||||||||||
| Male (n = 5311) | Female (n = 6587) | Total (n = 11898) | ||||||||||
| Screened No | ≥40 (U/L) No | Prevalence (%) | P-value for χ2 test for trend | Screened No | ≥40 (U/L) No | Prevalence (%) | P-value for χ2 test for trend | Screened No | ≥40 (U/L) No | Prevalence (%) | P-value for χ2 test for trend | |
| 30-39 | 1326 | 173 | 13.1 | 2215 | 96 | 4.3 | 3541 | 269 | 7.6 | |||
| 40-49 | 1255 | 144 | 11.5 | <0.0001 | 1581 | 94 | 6 | 0.192 | 2836 | 238 | 8.4 | <0.0001 |
| 50-59 | 1456 | 112 | 7.7 | 1224 | 75 | 6.1 | 2680 | 187 | 7 | |||
| 60-69 | 840 | 47 | 5.6 | 978 | 60 | 6.1 | 1818 | 107 | 5.9 | |||
| ≥70 | 434 | 24 | 5.5 | 589 | 26 | 4.4 | 1023 | 50 | 4.9 | |||
| Total | 5311 | 500 | 9.4 | 6587 | 351 | 5.3 | 11898 | 851 | 7.2 | |||
Table 2 Comparison of characteristics of elevated serum ALT level among subjects aged 30 and over in Kinmen (mean±SD).
| Variable | Level of ALT (U/L) | |||
| <40 (U/L)(n = 11 074) | ≥40 (U/L)(n = 851) | Total(n = 11 898) | P-valuefor t test | |
| Age (yr) | 49.7±13.3 | 47.912.2 | 49.613.2 | 0.0001 |
| BMI (kg/m2) | 23.3±3.4 | 24.63.4 | 23.43.5 | <0.0001 |
| Waist circumference (cm) | 82.7±10.1 | 86.69.7 | 83.110.2 | <0.0001 |
| FPG (mg/dL) | 100.3±28.2 | 105.4±28.8 | 100.9±28.2 | <0.0001 |
| SBP (mmHg) | 129.8±21.0 | 132.7±19.7 | 129.9±20.9 | <0.0001 |
| DBP (mmHg) | 80.0±12.4 | 83.5±12.0 | 80.3±12.4 | <0.0001 |
| Cholesterol (mg/dL) | 201.4±39.5 | 211.3±44.2 | 202.2±40.0 | <0.0001 |
| Triglyceride (mg/dL) | 91.8±57.7 | 120.9±79.2 | 93.9±60.0 | <0.0001 |
| HDL (mg/dL) | 56.5±20.0 | 55.9±23.9 | 56.5±20.5 | 0.49 |
| BUN (mg/dL) | 16.6±5.5 | 16.8±5.1 | 16.6±5.5 | 0.39 |
| Creatinine (mg/dL) | 0.79±0.31 | 0.84±0.26 | 0.79±0.31 | <0.0001 |
| Uric acid (mg/dL) | 5.5±1.6 | 6.3±1.7 | 5.6±1.6 | <0.0001 |
Table 3 Univariate analysis of associated factors for elevated serum alanine ALT level among subjects aged 30 and over in Kinmen.
| Elevated ALT level (≥40U/L) | Crude OR (95%CI) | Adjusted OR1 (95%CI) | ||
| Yes(n = 851) | No(n = 11074) | |||
| Gender Male | 500 | 4811 | 1.85 | - |
| Female | 351 | 6236 | (1.60-2.13) | - |
| Age (yr) 30-39 | 269 | 3272 | 1 | - |
| 40-49 | 238 | 2598 | 1.11(0.93-1.34) | - |
| 50-59 | 187 | 2493 | 0.91 (0.75-1.11) | - |
| 60-69 | 107 | 1711 | 0.76(0.60-0.96) | - |
| ≥70 | 50 | 973 | 0.63 (0.46-0.85) | - |
| Smoking Yes | 267 | 2941 | 1.26 | 0.87 |
| No | 584 | 8106 | (1.08-1.47) | (0.72-1.04) |
| Alcohol drinking Yes | 266 | 2362 | 1.67 | 1.24 |
| No | 585 | 8685 | (1.44-1.95) | (1.04-1.48) |
| Obesity Yes | 360 | 3032 | 1.94 | 2.05 |
| No | 491 | 8015 | (1.68-2.23) | (1.77-2.37) |
| High waist - Yes | 471 | 4599 | 1.72 | 2.41 |
| circumference No | 380 | 6388 | (1.50-1.98) | (2.07-2.80) |
| Type-2 diabetes Yes | 134 | 938 | 2.01 | 2.39 |
| No | 717 | 10109 | (1.66-2.45) | (1.94-2.93) |
| Hypertension Yes | 366 | 3850 | 1.41 | 1.54 |
| No | 485 | 7197 | (1.22-1.62) | (1.32-1.79) |
| Hyperchole-Yes | 205 | 1682 | 1.77 | 1.85 |
| sterolemia No | 646 | 9362 | (1.50-2.08) | (1.56-2.19) |
| Hypertrigly-Yes | 99 | 518 | 2.66 | 2.65 |
| ceridemia No | 745 | 10383 | (2.12-3.34) | (2.10-3.33) |
| Low HDL Yes | 138 | 1337 | 1.45 | 1.34 |
| No | 663 | 9324 | (1.20-1.76) | (1.10-1.63) |
| High BUN Yes | 193 | 2446 | 1.03 | 1.01 |
| No | 658 | 8598 | (0.87-1.22) | (0.85-1.20) |
| High creatinine Yes | 7 | 132 | 0.69 | 0.66 |
| No | 843 | 10909 | (0.32-1.47) | (0.31-1.42) |
| Hyperuricemia Yes | 342 | 2680 | 2.1 | 2.08 |
| No | 507 | 8355 | (1.82-2.43) | (1.79-2.40) |
Table 4 Multiple logistic regression of associated factors for elevated serum ALT level among subjects aged 30 and above in Kinmen.
| Variable | ALT (≥40 (U/L) vs <40 (U/L)) | |||||
| Male | Female | Total | ||||
| OR | 95%CI | OR | 95%CI | OR | 95%CI | |
| Gender (female vs male) | - | - | - | - | 0.21 | 0.11-0.38 |
| Age (yr) | 0.97 | 0.96-0.98 | 0.98 | 0.97-0.99 | 0.95 | 0.93-0.97 |
| Interaction between gender and age | - | - | - | - | 1.02 | 1.01-1.03 |
| Smoking (yes vs no) | 0.93 | 0.76-1.14 | 0.68 | 0.33-1.38 | 0.9 | 0.74-1.10 |
| Alcohol drinking (yes vs no) | 1.14 | 0.93-1.40 | 1.48 | 0.85-2.59 | 1.17 | 0.96-1.41 |
| Obesity (yes vs no) | 1.28 | 1.00-1.66 | 1.09 | 0.84-1.42 | 1.2 | 1.00-1.44 |
| High waist circumference (yes vs no) | 1.88 | 1.45-2.42 | 1.66 | 1.24-2.21 | 1.79 | 1.48-2.17 |
| Type-2 diabetes (yes vs no) | 1.74 | 1.28-2.37 | 1.56 | 1.11-2.21 | 1.7 | 1.35-2.13 |
| Hypertension (yes vs no) | 1.12 | 0.91-1.38 | 1.18 | 0.90-1.55 | 1.14 | 0.97-1.34 |
| Hypercholesterolemia (yes vs no) | 1.26 | 0.98-1.61 | 1.8 | 1.36-2.39 | 1.46 | 1.22-1.76 |
| Hypertriglyceridemia (yes vs no) | 1.3 | 0.91-1.85 | 1.61 | 1.03-2.52 | 1.40 | 1.06-1.84 |
| Low HDL (yes vs no) | 0.96 | 0.74-1.25 | 1.12 | 0.79-1.60 | 1.02 | 0.82-1.25 |
| High BUN (yes vs no) | 0.92 | 0.73-1.16 | 1.1 | 0.82-1.48 | 0.99 | 0.82-1.19 |
| High creatinine (yes vs no) | 0.55 | 0.22-1.40 | 0.25 | 0.03-1.89 | 0.46 | 0.20-1.06 |
| Hyperuricemia (yes vs no) | 1.47 | 1.19-1.80 | 1.92 | 1.49-2.48 | 1.63 | 1.39-1.92 |
- Citation: Liu CM, Tung TH, Liu JH, Chen VTK, Lin CH, Hsu CT, Chou P. A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan. World J Gastroenterol 2005; 11(11): 1616-1622
- URL: https://www.wjgnet.com/1007-9327/full/v11/i11/1616.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i11.1616